TY - JOUR
T1 - Circuit organization of the excitatory sensorimotor loop through hand/forelimb s1 and m1
AU - Yamawaki, Naoki
AU - Tapies, Martinna G.Raineri
AU - Stults, Austin
AU - Smith, Gregory A.
AU - Shepherd, Gordon M.G.
N1 - Funding Information:
We thank John Barrett and Yutaka Yoshida for comments and suggestions, Frances Hausmann for technical assistance, and, for provision of PRV viruses, Jeffrey Friedman (Rockefeller), Oliver Huang (Princeton), Lisa Pomeranz (Rockefeller), and the Center for Neuroanatomy with Neurotropic Viruses (CNNV, University of Pittsburgh). Funding support was from NIH grants including NINDS R01 NS061963 (GMGS); NIAID R01 AI056346 (GAS); NIH Virus Center P40 OD010996 (CNNV).
Publisher Copyright:
© Yamawaki et al.
PY - 2021
Y1 - 2021
N2 - Sensory-guided limb control relies on communication across sensorimotor loops. For active touch with the hand, the longest loop is the transcortical continuation of ascending pathways, particularly the lemnisco-cortical and corticocortical pathways carrying tactile signals via the cuneate nucleus, ventral posterior lateral (VPL) thalamus, and primary somatosensory (S1) and motor (M1) cortices to reach corticospinal neurons and influence descending activity. We characterized excitatory connectivity along this pathway in the mouse. In the lemnisco-cortical leg, disynaptic cuneate→VPL→S1 connections excited mainly layer (L) 4 neurons. In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons. The findings provide a detailed new wiring diagram for the hand/forelimb-related transcortical circuit, delineating a basic but complex set of cell-type-specific feedforward excitatory connections that selectively and extensively engage diverse intratelencephalic projection neurons, thereby polysynaptically linking subcortical somatosensory input to cortical motor output to spinal cord.
AB - Sensory-guided limb control relies on communication across sensorimotor loops. For active touch with the hand, the longest loop is the transcortical continuation of ascending pathways, particularly the lemnisco-cortical and corticocortical pathways carrying tactile signals via the cuneate nucleus, ventral posterior lateral (VPL) thalamus, and primary somatosensory (S1) and motor (M1) cortices to reach corticospinal neurons and influence descending activity. We characterized excitatory connectivity along this pathway in the mouse. In the lemnisco-cortical leg, disynaptic cuneate→VPL→S1 connections excited mainly layer (L) 4 neurons. In the corticocortical leg, S1→M1 connections from L2/3 and L5A neurons mainly excited downstream L2/3 neurons, which excite corticospinal neurons. The findings provide a detailed new wiring diagram for the hand/forelimb-related transcortical circuit, delineating a basic but complex set of cell-type-specific feedforward excitatory connections that selectively and extensively engage diverse intratelencephalic projection neurons, thereby polysynaptically linking subcortical somatosensory input to cortical motor output to spinal cord.
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U2 - 10.7554/ELIFE.66836
DO - 10.7554/ELIFE.66836
M3 - Article
C2 - 33851917
AN - SCOPUS:85104308325
VL - 10
JO - eLife
JF - eLife
SN - 2050-084X
M1 - e66836
ER -