Circularly permuted DNA, RNA and proteins - a review

Tao Pan, Olke C. Uhlenbeck*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

47 Scopus citations


Circular permutation represents a form of macromolecular isomerization when the normal termini are covalently linked and new termini introduced by breaking the backbone elsewhere. Here, we describe implications of circular permutation on the folding and function of biologically relevant macromolecules. A method permitting the analysis of the folding of all circularly permuted isomers of RNA is presented that has been successfully applied for a tRNA and the binding site of the coliphage R 17 coat protein.

Original languageEnglish (US)
Pages (from-to)111-114
Number of pages4
Issue number2
StatePublished - Mar 30 1993


  • Bacteriophage T4
  • RNA and protein folding
  • RNA-protein interactions
  • circular permutation analysis

ASJC Scopus subject areas

  • Genetics


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