Circularly permuted DNA, RNA and proteins - a review

Tao Pan; Olke C. Uhlenbeck

doi:10.1016/0378-1119(93)90317-V

Circularly permuted DNA, RNA and proteins - a review

Tao Pan, Olke C. Uhlenbeck^*

^*Corresponding author for this work

Molecular Biosciences

Research output: Contribution to journal › Article › peer-review

47 Scopus citations

Abstract

Circular permutation represents a form of macromolecular isomerization when the normal termini are covalently linked and new termini introduced by breaking the backbone elsewhere. Here, we describe implications of circular permutation on the folding and function of biologically relevant macromolecules. A method permitting the analysis of the folding of all circularly permuted isomers of RNA is presented that has been successfully applied for a tRNA and the binding site of the coliphage R 17 coat protein.

Original language	English (US)
Pages (from-to)	111-114
Number of pages	4
Journal	Gene
Volume	125
Issue number	2
DOIs	https://doi.org/10.1016/0378-1119(93)90317-V
State	Published - Mar 30 1993

Keywords

Bacteriophage T4
RNA and protein folding
RNA-protein interactions
circular permutation analysis

ASJC Scopus subject areas

Genetics

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10.1016/0378-1119(93)90317-V

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AU - Uhlenbeck, Olke C.

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AB - Circular permutation represents a form of macromolecular isomerization when the normal termini are covalently linked and new termini introduced by breaking the backbone elsewhere. Here, we describe implications of circular permutation on the folding and function of biologically relevant macromolecules. A method permitting the analysis of the folding of all circularly permuted isomers of RNA is presented that has been successfully applied for a tRNA and the binding site of the coliphage R 17 coat protein.

KW - Bacteriophage T4

KW - RNA and protein folding

KW - RNA-protein interactions

KW - circular permutation analysis

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Circularly permuted DNA, RNA and proteins - a review

Abstract

Keywords

ASJC Scopus subject areas

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