Circulating 25-hydroxyVitamin D and physical performance in older adults: A nationwide study in Taiwan

Shu Chun Chuang, Hui Ling Chen, Wei Ting Tseng, I. Chien Wu, Chih Cheng Hsu, Hsing Yi Chang, Yii Der Ida Chen, Marion M. Lee, Kiang Liu, Chao Agnes Hsiung*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Background: A previous study indicated that 31% of the elderly in Taiwan have a Vitamin D deficiency. Vitamin D adequacy has been associated with physical performance in the elderly. Objectives: The first aim of the current study was to identify the determinants for Vitamin D deficiency. The second aim was to evaluate the association between Vitamin D status and physical performance. Design: A total of 5664 community-dwelling participants aged 55 y were recruited since 2008. Plasma total 25-hydroxyVitamin D concentrations were originally determined by ELISA and calibrated to a chemiluminescence measurement. Physical performance was assessed by handgrip strength, the Short Physical Performance Battery, timed up and go, a 6-min walk test, and single-leg stands. Multiple linear regression and logistic regression were used to estimate the cross-sectional associations. Results: Vitamin D inadequacy (,50 nmol/L) was related to higher education (P-trend , 0.01), body mass index [(BMI; in kg/m2) ORs (95% CIs) for 30 compared with 18.5 to ,25 were 1.78 (1.14, 2.78) for men and 1.53 (1.11, 2.11) for women], and vegetable intake [fourth compared with first quartile, 1.58 (1.15, 2.18) for men and 2.38 (1.82, 3.12) for women]. Higher intakes of fish [fourth compared with first quartile, 0.44 (0.33, 0.59) for men and 0.27 (0.21, 0.36) for women] and milk [fourth compared with first quartile, 0.46 (0.31, 0.69) for men and 0.69 (0.49, 0.95) for women] were associated with lower risk of Vitamin D inadequacy. Few subjects had 25-hydroxyVitamin D concentrations ,30 nmol/L. Above that concentration, there was no doseeffect relation with physical performance except for single-leg stands. Conclusions: The factors associated with Vitamin D inadequacy in Taiwan were higher education, higher BMI, and lower fish and milk intakes. No dose-effect relation existed between Vitamin D concentration and physical performance except for single-leg stands.

Original languageEnglish (US)
Pages (from-to)1334-1344
Number of pages11
JournalAmerican Journal of Clinical Nutrition
Issue number5
StatePublished - Nov 1 2016


  • Epidemiology
  • Lifestyle factors
  • Physical performance
  • Vitamin D

ASJC Scopus subject areas

  • Nutrition and Dietetics
  • Medicine (miscellaneous)


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