Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia

Mihaela Onciu; Elihu Estey; Francis J. Giles

doi:10.1080/10245330310001604737

Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia

Mihaela Onciu, Elihu Estey, Francis J. Giles^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 10⁹/l in 13 of 30 (43%) samples, and platelets > 100 × 10⁹/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

Original language	English (US)
Pages (from-to)	295-301
Number of pages	7
Journal	Hematology
Volume	8
Issue number	5
DOIs	https://doi.org/10.1080/10245330310001604737
State	Published - Oct 2003

Keywords

Acute leukemia
Blasts
Chemotherapy
Peripheral blood
Remission

ASJC Scopus subject areas

Hematology

Access to Document

10.1080/10245330310001604737

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title = "Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia",

abstract = "We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43%) samples, and platelets > 100 × 109/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).",

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AU - Giles, Francis J.

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AB - We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43%) samples, and platelets > 100 × 109/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

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KW - Chemotherapy

KW - Peripheral blood

KW - Remission

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