Circulating blasts following chemotherapy in pediatric patients: Implications for complete remission definition in acute leukemia

Mihaela Onciu, Elihu Estey, Francis J. Giles*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43%) samples, and platelets > 100 × 109/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).

Original languageEnglish (US)
Pages (from-to)295-301
Number of pages7
JournalHematology
Volume8
Issue number5
DOIs
StatePublished - Oct 2003

Keywords

  • Acute leukemia
  • Blasts
  • Chemotherapy
  • Peripheral blood
  • Remission

ASJC Scopus subject areas

  • Hematology

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