Abstract
We assessed the incidence of circulating blasts occurring post-chemotherapy in 1000 consecutive pediatric blood samples. Blasts with myeloid morphology (<1-3%) were present in post-chemotherapy samples in 19 of 294 (6.4%) patients with acute leukemia in remission and in 11 of 361 (3.4%) patients with solid tumors, non-Hodgkin or Hodgkin lymphoma, and were associated with ANC > 1.5 × 109/l in 13 of 30 (43%) samples, and platelets > 100 × 109/l in 25 of 30 (83%) samples. Our findings suggest that the absence of circulating blasts may not be a prerequisite for remission in acute myeloid leukemia (AML).
Original language | English (US) |
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Pages (from-to) | 295-301 |
Number of pages | 7 |
Journal | Hematology |
Volume | 8 |
Issue number | 5 |
DOIs | |
State | Published - Oct 2003 |
Keywords
- Acute leukemia
- Blasts
- Chemotherapy
- Peripheral blood
- Remission
ASJC Scopus subject areas
- Hematology