Abstract
Branched chain amino acids (BCAAs) are essential for protein homeostasis, energy balance, and signaling pathways. Changes in BCAA homeostasis have emerged as pivotal contributors in the pathophysiology of several cardiometabolic diseases, including type 2 diabetes, obesity, hypertension, atherosclerotic cardiovascular disease, and heart failure. In this review, we provide a detailed overview of BCAA metabolism, focus on molecular mechanisms linking disrupted BCAA homeostasis with cardiometabolic disease, summarize the evidence from observational and interventional studies investigating associations between circulating BCAAs and cardiometabolic disease, and offer valuable insights into the potential for BCAA manipulation as a novel therapeutic strategy for cardiometabolic disease.
| Original language | English (US) |
|---|---|
| Article number | e031617 |
| Journal | Journal of the American Heart Association |
| Volume | 13 |
| Issue number | 7 |
| DOIs | |
| State | Published - Apr 2 2024 |
Funding
This research was supported by the National Institutes of Health under grants R01 HL146844 (Dr Wilkins) and T32 HL069771 (Dr Sawicki). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Keywords
- biochemistry
- cardiovascular disease
- epidemiologic studies
- inflammation
- metabolism
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
