Circulating endocannabinoids and affect regulation in human subjects

Emil F. Coccaro*, Matthew N. Hill, Lauren Robinson, Royce J. Lee

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


The endocannabinoid (EC) system influences a wide variety of neurobiological processes including affect and emotionality as well as other neuropsychiatric functions. In this study we examined the relationship of circulating endocannabinoids [anandamide (AEA) and 2-arachidonoylglycerol (2-AG)] with affect and emotionality in 175 individuals with (n = 115) and without (n = 60) mood, anxiety, and/or personality disorders. Circulating AEA levels displayed a modest, though statistically significant, inverse relationship with a composite measure of affect regulation (β = − 0.264, p = 0.009), due to its relationship with affect intensity (β = − 0.225, p = 0.021) across all study participants. Neither AEA nor 2-AG level differed as a function of any syndromal/personality disorder and neither correlated significantly with state depression or state anxiety scores. These data suggest that circulating levels endocannabinoids may play a role in emotionality across individuals regardless of defined psychiatric disorder.

Original languageEnglish (US)
Pages (from-to)66-71
Number of pages6
StatePublished - Jun 2018


  • Affect regulation
  • Anxiety
  • Depression
  • Endocannabinoids

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Psychiatry and Mental health
  • Biological Psychiatry


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