Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia

Chen Hsiung Yeh; Richard Tseng; Zhong Zhang; Jorge Cortes; Susan O'Brien; Francis Giles; Alison Hannah; Zeev Estrov; Michael Keating; Hagop Kantarjian; Maher Albitar

doi:10.1016/j.leukres.2008.07.012

Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia

Chen Hsiung Yeh, Richard Tseng, Zhong Zhang, Jorge Cortes, Susan O'Brien, Francis Giles, Alison Hannah, Zeev Estrov, Michael Keating, Hagop Kantarjian, Maher Albitar^*

^*Corresponding author for this work

Medicine, Hematology Oncology Division

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

We evaluated the association of circulating levels of heat shock protein 70 (Hsp70) in plasma with clinical behavior and progression in 139 chronic myeloid leukemia (CML) patients. Circulating Hsp70 levels did not differ significantly between CML patients in the chronic phase (n = 93; median 33.24 ng/mL, range 3.89-128.2 ng/mL) and those in the accelerated/blast phase (n = 46; median 26.57 ng/mL, range 4.5-114.7 ng/mL). However, overall CML patients had significantly higher levels of Hsp70 than healthy subjects (n = 95, median 4.17 ng/mL, range 1.75-24.7 ng/mL) (P < 0.001). In chronic phase CML patients, Hsp70 levels above the median were associated with a higher rate of progression to the accelerated/blast phase and a tendency toward shorter survival. Plasma Hsp70 thus could be a potential marker for predicting disease progression in patients with chronic phase CML.

Original language	English (US)
Pages (from-to)	212-217
Number of pages	6
Journal	Leukemia Research
Volume	33
Issue number	2
DOIs	https://doi.org/10.1016/j.leukres.2008.07.012
State	Published - Feb 2009

Keywords

Chronic myeloid leukemia
Circulating heat shock protein
Imatinib resistance

ASJC Scopus subject areas

Hematology
Oncology
Cancer Research

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.leukres.2008.07.012

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title = "Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia",

abstract = "We evaluated the association of circulating levels of heat shock protein 70 (Hsp70) in plasma with clinical behavior and progression in 139 chronic myeloid leukemia (CML) patients. Circulating Hsp70 levels did not differ significantly between CML patients in the chronic phase (n = 93; median 33.24 ng/mL, range 3.89-128.2 ng/mL) and those in the accelerated/blast phase (n = 46; median 26.57 ng/mL, range 4.5-114.7 ng/mL). However, overall CML patients had significantly higher levels of Hsp70 than healthy subjects (n = 95, median 4.17 ng/mL, range 1.75-24.7 ng/mL) (P < 0.001). In chronic phase CML patients, Hsp70 levels above the median were associated with a higher rate of progression to the accelerated/blast phase and a tendency toward shorter survival. Plasma Hsp70 thus could be a potential marker for predicting disease progression in patients with chronic phase CML.",

keywords = "Chronic myeloid leukemia, Circulating heat shock protein, Imatinib resistance",

author = "Yeh, {Chen Hsiung} and Richard Tseng and Zhong Zhang and Jorge Cortes and Susan O'Brien and Francis Giles and Alison Hannah and Zeev Estrov and Michael Keating and Hagop Kantarjian and Maher Albitar",

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doi = "10.1016/j.leukres.2008.07.012",

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AU - Yeh, Chen Hsiung

AU - Tseng, Richard

AU - Zhang, Zhong

AU - Cortes, Jorge

AU - O'Brien, Susan

AU - Giles, Francis

AU - Hannah, Alison

AU - Estrov, Zeev

AU - Keating, Michael

AU - Kantarjian, Hagop

AU - Albitar, Maher

PY - 2009/2

Y1 - 2009/2

N2 - We evaluated the association of circulating levels of heat shock protein 70 (Hsp70) in plasma with clinical behavior and progression in 139 chronic myeloid leukemia (CML) patients. Circulating Hsp70 levels did not differ significantly between CML patients in the chronic phase (n = 93; median 33.24 ng/mL, range 3.89-128.2 ng/mL) and those in the accelerated/blast phase (n = 46; median 26.57 ng/mL, range 4.5-114.7 ng/mL). However, overall CML patients had significantly higher levels of Hsp70 than healthy subjects (n = 95, median 4.17 ng/mL, range 1.75-24.7 ng/mL) (P < 0.001). In chronic phase CML patients, Hsp70 levels above the median were associated with a higher rate of progression to the accelerated/blast phase and a tendency toward shorter survival. Plasma Hsp70 thus could be a potential marker for predicting disease progression in patients with chronic phase CML.

AB - We evaluated the association of circulating levels of heat shock protein 70 (Hsp70) in plasma with clinical behavior and progression in 139 chronic myeloid leukemia (CML) patients. Circulating Hsp70 levels did not differ significantly between CML patients in the chronic phase (n = 93; median 33.24 ng/mL, range 3.89-128.2 ng/mL) and those in the accelerated/blast phase (n = 46; median 26.57 ng/mL, range 4.5-114.7 ng/mL). However, overall CML patients had significantly higher levels of Hsp70 than healthy subjects (n = 95, median 4.17 ng/mL, range 1.75-24.7 ng/mL) (P < 0.001). In chronic phase CML patients, Hsp70 levels above the median were associated with a higher rate of progression to the accelerated/blast phase and a tendency toward shorter survival. Plasma Hsp70 thus could be a potential marker for predicting disease progression in patients with chronic phase CML.

KW - Chronic myeloid leukemia

KW - Circulating heat shock protein

KW - Imatinib resistance

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Circulating heat shock protein 70 and progression in patients with chronic myeloid leukemia

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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