Circulating keratan sulfate: A marker of cartilage proteoglycan catabolism in osteoarthritis

E. J. Thonar, D. M. Manicourt, J. Williams, M. E. Lenz, M. B. Sweet, T. J. Schnitzer, L. Otten, T. Glant, K. E. Kuettner

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

The serum level of a highly sulfated epitope present on long keratan sulfate chains provides a direct measure of the rate of catabolism of cartilage proteoglycans. Levels of the keratan sulfate epitope are elevated in patients with generalized osteoarthritis (OA), indicating these individuals have elevated rates of cartilage proteoglycan catabolism. In the Pond-Nuki model of canine OA, the serum level of the keratan sulfate epitope rises rapidly after the transection of the anterior cruciate ligament, long before OA lesions can be detected, and remains high for at least 13 weeks.

Original languageEnglish (US)
Pages (from-to)24-26
Number of pages3
JournalJournal of Rheumatology
Volume18
Issue numberSUPPL. 27
StatePublished - 1991

Keywords

  • Articular cartilage
  • Catabolism
  • ELISA
  • Keratan sulfate
  • Osteoarthritis
  • Proteoglycan

ASJC Scopus subject areas

  • Rheumatology
  • Immunology and Allergy
  • Immunology

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