TY - JOUR
T1 - Circulating microRNAs as biomarkers for inflammatory diseases
AU - Mi, Shuangli
AU - Zhang, Jian
AU - Zhang, Wei
AU - Huang, R. Stephanie
PY - 2013
Y1 - 2013
N2 - MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.
AB - MicroRNAs (miRNAs), a class of small, non-coding RNA molecules with gene regulatory functions, have emerged to play a critical role in the pathogenesis of a variety of diseases. Current technological advances allow accurate, high throughput profiling of miRNA abundance in different tissues. More recently, extracellular, circulating miRNAs have begun to be demonstrated as highly stable, blood-based biomarkers for diseases. Understanding the interactions between circulating miRNAs and clinical phenotypes can enhance our knowledge of complex diseases and traits. On the other hand, given the advantages of utilizing blood-based biomarkers (e.g., convenience in collecting samples), circulating miRNAs as biomarkers may improve both disease diagnosis and management. Particularly, we reviewed recent progress in identifying circulating miRNAs as biomarkers for several common inflammatory diseases including asthma, inflammatory bowel disease, and rheumatoid arthritis. Current studies showed a promising future of using circulating miRNAs in the care of inflammatory diseases.
KW - Asthma
KW - biomarkers
KW - circulating markers
KW - inflammatory bowl disease
KW - microRNA
KW - rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=84925884839&partnerID=8YFLogxK
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U2 - 10.2174/2211536611302010007
DO - 10.2174/2211536611302010007
M3 - Review article
C2 - 25019052
AN - SCOPUS:84925884839
SN - 2211-5366
VL - 2
SP - 63
EP - 71
JO - MicroRNA (Shāriqah, United Arab Emirates)
JF - MicroRNA (Shāriqah, United Arab Emirates)
IS - 1
ER -