Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck

Ethan J. Harris; Julian Huang; Erin Carroll; Alarice C. Lowe; Nicole G. Chau; Guilherme Rabinowits; Robert Haddad; Glenn J. Hanna; Tyler Haddad; Matthew Sanborn; Alec Kacew; Jochen Lorch

doi:10.1002/lio2.448

Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck

Ethan J. Harris, Julian Huang, Erin Carroll, Alarice C. Lowe, Nicole G. Chau, Guilherme Rabinowits, Robert Haddad, Glenn J. Hanna, Tyler Haddad, Matthew Sanborn, Alec Kacew, Jochen Lorch^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Background: Circulating tumors cells (CTCs) are considered an early step towards metastasis and have been linked to poor prognosis in several types of cancer. CTCs in squamous cell carcinoma of the head and neck (SCCHN) have an unclear role. Methods: In this prospective study, patients with locally advanced or metastatic SCCHN had CTC counts assessed before starting systemic treatment using the CellSearch System. Select cases also had sequential CTC evaluation. Presence of CTCs was correlated with patient characteristics and outcomes. Results: Forty-eight patients enrolled, and 36 had evaluable clinical data and baseline CTC counts. Twenty-five patients had locally advanced disease (LAD) and 11 had metastatic disease. ≥1 CTCs were detected in six patients with LAD (24%) and four with metastatic disease (36%). On univariate analysis, smoking was associated with CTCs. Conclusion: CTCs are not associated with prognosis in patients with LAD and metastatic disease; however, they are present in this patient population, and ≥1 CTCs is associated with a history of smoking. Level of evidence: 1b; individual prospective cohort study.

Original language	English (US)
Pages (from-to)	1063-1069
Number of pages	7
Journal	Laryngoscope investigative otolaryngology
Volume	5
Issue number	6
DOIs	https://doi.org/10.1002/lio2.448
State	Published - Dec 2020
Externally published	Yes

Keywords

circulating tumor cells
head and neck cancer
smoking

ASJC Scopus subject areas

Surgery
Otorhinolaryngology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/lio2.448

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@article{d69b1cec187e45b79e21677fd419eaaa,

title = "Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck",

abstract = "Background: Circulating tumors cells (CTCs) are considered an early step towards metastasis and have been linked to poor prognosis in several types of cancer. CTCs in squamous cell carcinoma of the head and neck (SCCHN) have an unclear role. Methods: In this prospective study, patients with locally advanced or metastatic SCCHN had CTC counts assessed before starting systemic treatment using the CellSearch System. Select cases also had sequential CTC evaluation. Presence of CTCs was correlated with patient characteristics and outcomes. Results: Forty-eight patients enrolled, and 36 had evaluable clinical data and baseline CTC counts. Twenty-five patients had locally advanced disease (LAD) and 11 had metastatic disease. ≥1 CTCs were detected in six patients with LAD (24%) and four with metastatic disease (36%). On univariate analysis, smoking was associated with CTCs. Conclusion: CTCs are not associated with prognosis in patients with LAD and metastatic disease; however, they are present in this patient population, and ≥1 CTCs is associated with a history of smoking. Level of evidence: 1b; individual prospective cohort study.",

keywords = "circulating tumor cells, head and neck cancer, smoking",

author = "Harris, {Ethan J.} and Julian Huang and Erin Carroll and Lowe, {Alarice C.} and Chau, {Nicole G.} and Guilherme Rabinowits and Robert Haddad and Hanna, {Glenn J.} and Tyler Haddad and Matthew Sanborn and Alec Kacew and Jochen Lorch",

note = "Funding Information: Glenn J. Hanna received grant or institutional research support from BMS, Exicure, GSK, Altor BioScience, Kite, Regeneron, Sanofi/Genzyme, and Kartos; received consulting and honoraria from Regeneron, Sanofi, BMS, Maverick, and Merck. Guilherme Rabinowits received support from the consulting/advisory board: Merck, Regeneron, Sanofi, EMD Serono, Pfizer, Castle. Shares: Regeneron and Syros Pharmaceuticals. Publisher Copyright: {\textcopyright} 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC. on behalf of The Triological Society.",

year = "2020",

month = dec,

doi = "10.1002/lio2.448",

language = "English (US)",

volume = "5",

pages = "1063--1069",

journal = "Laryngoscope investigative otolaryngology",

issn = "2378-8039",

publisher = "Wiley-Blackwell",

number = "6",

}

TY - JOUR

T1 - Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck

AU - Harris, Ethan J.

AU - Huang, Julian

AU - Carroll, Erin

AU - Lowe, Alarice C.

AU - Chau, Nicole G.

AU - Rabinowits, Guilherme

AU - Haddad, Robert

AU - Hanna, Glenn J.

AU - Haddad, Tyler

AU - Sanborn, Matthew

AU - Kacew, Alec

AU - Lorch, Jochen

N1 - Funding Information: Glenn J. Hanna received grant or institutional research support from BMS, Exicure, GSK, Altor BioScience, Kite, Regeneron, Sanofi/Genzyme, and Kartos; received consulting and honoraria from Regeneron, Sanofi, BMS, Maverick, and Merck. Guilherme Rabinowits received support from the consulting/advisory board: Merck, Regeneron, Sanofi, EMD Serono, Pfizer, Castle. Shares: Regeneron and Syros Pharmaceuticals. Publisher Copyright: © 2020 The Authors. Laryngoscope Investigative Otolaryngology published by Wiley Periodicals LLC. on behalf of The Triological Society.

PY - 2020/12

Y1 - 2020/12

N2 - Background: Circulating tumors cells (CTCs) are considered an early step towards metastasis and have been linked to poor prognosis in several types of cancer. CTCs in squamous cell carcinoma of the head and neck (SCCHN) have an unclear role. Methods: In this prospective study, patients with locally advanced or metastatic SCCHN had CTC counts assessed before starting systemic treatment using the CellSearch System. Select cases also had sequential CTC evaluation. Presence of CTCs was correlated with patient characteristics and outcomes. Results: Forty-eight patients enrolled, and 36 had evaluable clinical data and baseline CTC counts. Twenty-five patients had locally advanced disease (LAD) and 11 had metastatic disease. ≥1 CTCs were detected in six patients with LAD (24%) and four with metastatic disease (36%). On univariate analysis, smoking was associated with CTCs. Conclusion: CTCs are not associated with prognosis in patients with LAD and metastatic disease; however, they are present in this patient population, and ≥1 CTCs is associated with a history of smoking. Level of evidence: 1b; individual prospective cohort study.

AB - Background: Circulating tumors cells (CTCs) are considered an early step towards metastasis and have been linked to poor prognosis in several types of cancer. CTCs in squamous cell carcinoma of the head and neck (SCCHN) have an unclear role. Methods: In this prospective study, patients with locally advanced or metastatic SCCHN had CTC counts assessed before starting systemic treatment using the CellSearch System. Select cases also had sequential CTC evaluation. Presence of CTCs was correlated with patient characteristics and outcomes. Results: Forty-eight patients enrolled, and 36 had evaluable clinical data and baseline CTC counts. Twenty-five patients had locally advanced disease (LAD) and 11 had metastatic disease. ≥1 CTCs were detected in six patients with LAD (24%) and four with metastatic disease (36%). On univariate analysis, smoking was associated with CTCs. Conclusion: CTCs are not associated with prognosis in patients with LAD and metastatic disease; however, they are present in this patient population, and ≥1 CTCs is associated with a history of smoking. Level of evidence: 1b; individual prospective cohort study.

KW - circulating tumor cells

KW - head and neck cancer

KW - smoking

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DO - 10.1002/lio2.448

M3 - Article

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SN - 2378-8039

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SP - 1063

EP - 1069

JO - Laryngoscope investigative otolaryngology

JF - Laryngoscope investigative otolaryngology

IS - 6

ER -

Circulating tumor cell analysis in locally advanced and metastatic squamous cell carcinoma of the head and neck

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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