@article{825d226b84b142b6be915845e911cdc4,
title = "Circulating tumor cell profiling for precision oncology",
abstract = "Analysis of circulating tumor cells (CTCs) collected from patient's blood offers a broad range of opportunities in the field of precision oncology. With new advances in profiling technology, it is now possible to demonstrate an association between the molecular profiles of CTCs and tumor response to therapy. In this Review, we discuss mechanisms of tumor resistance to therapy and their link to phenotypic and genotypic properties of CTCs. We summarize key technologies used to isolate and analyze CTCs and discuss recent clinical studies that examined CTCs for genomic and proteomic predictors of responsiveness to therapy. We also point out current limitations that still hamper the implementation of CTCs into clinical practice. We finally reflect on how these shortcomings can be addressed with the likely contribution of multiparametric approaches and advanced data analytics.",
keywords = "CTC enrichment, drug selection, microfluidics, molecular profiling, precision oncology, tumor resistance",
author = "Mahmoud Labib and Kelley, {Shana O.}",
note = "Funding Information: We thank the Canadian Institutes of Health Research (Grant #FDN-148415), the Natural Sciences and Engineering Research Council of Canada (Grant #2016-06090), the Province of Ontario though the Ministry of Research, Innovation and Science (Grant #RE05-009), and the National Cancer Institute of the National Institutes of Health (Grant #1R33CA204574). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the other funding agencies. Funding Information: We thank the Canadian Institutes of Health Research (Grant #FDN‐148415), the Natural Sciences and Engineering Research Council of Canada (Grant #2016‐06090), the Province of Ontario though the Ministry of Research, Innovation and Science (Grant #RE05‐009), and the National Cancer Institute of the National Institutes of Health (Grant #1R33CA204574). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the other funding agencies. Publisher Copyright: {\textcopyright} 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies.",
year = "2021",
month = jun,
doi = "10.1002/1878-0261.12901",
language = "English (US)",
volume = "15",
pages = "1622--1646",
journal = "Molecular oncology",
issn = "1574-7891",
publisher = "Elsevier",
number = "6",
}
