Cirrhosis and Portal Hypertension in the Pediatric Population

Catherine Ann Chapin, Lee M Bass*

*Corresponding author for this work

Research output: Contribution to journalReview article

5 Scopus citations

Abstract

Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obstruction, biliary atresia, alpha 1 antitrypsin deficiency, and autoimmune hepatitis. Gastroesophageal varices and ascites are two of the complications of portal hypertension likely to cause morbidity and mortality. This review also discusses extrahepatic manifestations of portal hypertension and treatment options.

Original languageEnglish (US)
Pages (from-to)735-752
Number of pages18
JournalClinics in liver disease
Volume22
Issue number4
DOIs
StatePublished - Nov 1 2018

Keywords

  • Ascites
  • Biliary atresia
  • Children
  • Cirrhosis
  • Esophageal varices
  • Portal hypertension

ASJC Scopus subject areas

  • Hepatology

Fingerprint Dive into the research topics of 'Cirrhosis and Portal Hypertension in the Pediatric Population'. Together they form a unique fingerprint.

  • Cite this