Cirrhosis and Portal Hypertension in the Pediatric Population

Catherine Ann Chapin, Lee M Bass*

*Corresponding author for this work

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obstruction, biliary atresia, alpha 1 antitrypsin deficiency, and autoimmune hepatitis. Gastroesophageal varices and ascites are two of the complications of portal hypertension likely to cause morbidity and mortality. This review also discusses extrahepatic manifestations of portal hypertension and treatment options.

Original languageEnglish (US)
Pages (from-to)735-752
Number of pages18
JournalClinics in liver disease
Volume22
Issue number4
DOIs
StatePublished - Nov 1 2018

Fingerprint

Portal Hypertension
Fibrosis
Pediatrics
Population
alpha 1-Antitrypsin Deficiency
Biliary Atresia
Autoimmune Hepatitis
Varicose Veins
Portal Vein
Ascites
Morbidity
Mortality
Liver
Therapeutics

Keywords

  • Ascites
  • Biliary atresia
  • Children
  • Cirrhosis
  • Esophageal varices
  • Portal hypertension

ASJC Scopus subject areas

  • Hepatology

Cite this

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title = "Cirrhosis and Portal Hypertension in the Pediatric Population",
abstract = "Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obstruction, biliary atresia, alpha 1 antitrypsin deficiency, and autoimmune hepatitis. Gastroesophageal varices and ascites are two of the complications of portal hypertension likely to cause morbidity and mortality. This review also discusses extrahepatic manifestations of portal hypertension and treatment options.",
keywords = "Ascites, Biliary atresia, Children, Cirrhosis, Esophageal varices, Portal hypertension",
author = "Chapin, {Catherine Ann} and Bass, {Lee M}",
year = "2018",
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doi = "10.1016/j.cld.2018.06.007",
language = "English (US)",
volume = "22",
pages = "735--752",
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}

Cirrhosis and Portal Hypertension in the Pediatric Population. / Chapin, Catherine Ann; Bass, Lee M.

In: Clinics in liver disease, Vol. 22, No. 4, 01.11.2018, p. 735-752.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Cirrhosis and Portal Hypertension in the Pediatric Population

AU - Chapin, Catherine Ann

AU - Bass, Lee M

PY - 2018/11/1

Y1 - 2018/11/1

N2 - Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obstruction, biliary atresia, alpha 1 antitrypsin deficiency, and autoimmune hepatitis. Gastroesophageal varices and ascites are two of the complications of portal hypertension likely to cause morbidity and mortality. This review also discusses extrahepatic manifestations of portal hypertension and treatment options.

AB - Cirrhosis is a complex process in which the architecture of the liver is replaced by structurally abnormal nodules due to cirrhosis. Cirrhosis frequently leads to the development of portal hypertension. In children, portal hypertension may be caused by a wide range of etiologies, including extrahepatic portal vein obstruction, biliary atresia, alpha 1 antitrypsin deficiency, and autoimmune hepatitis. Gastroesophageal varices and ascites are two of the complications of portal hypertension likely to cause morbidity and mortality. This review also discusses extrahepatic manifestations of portal hypertension and treatment options.

KW - Ascites

KW - Biliary atresia

KW - Children

KW - Cirrhosis

KW - Esophageal varices

KW - Portal hypertension

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U2 - 10.1016/j.cld.2018.06.007

DO - 10.1016/j.cld.2018.06.007

M3 - Review article

C2 - 30266160

AN - SCOPUS:85051962292

VL - 22

SP - 735

EP - 752

JO - Clinics in Liver Disease

JF - Clinics in Liver Disease

SN - 1089-3261

IS - 4

ER -