Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet

Fabiana Quagliarini, Ashfaq Ali Mir, Kinga Balazs, Michael Wierer, Kenneth Allen Dyar, Celine Jouffe, Konstantinos Makris, Johann Hawe, Matthias Heinig, Fabian Volker Filipp, Grant Daniel Barish, Nina Henriette Uhlenhaut*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Glucocorticoid hormones are secreted with a prominent daily rhythm, but their diurnal genomic actions remain uncharacterized. Quagliarini et al. show how the glucocorticoid receptor controls daily cycles of glucose and triglyceride metabolism by time-dependent chromatin binding and target gene transcription and how this rhythm is augmented by high-fat diet.

Original languageEnglish (US)
Pages (from-to)531-545.e5
JournalMolecular cell
Volume76
Issue number4
DOIs
StatePublished - Nov 21 2019

Keywords

  • PPARα
  • STAT5
  • circadian clock
  • cistromes
  • glucocorticoid receptor
  • glucose and lipid metabolism
  • high-fat diet
  • hormones
  • mouse liver

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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