CITED1 expression in wilms' tumor and embryonic kidney

Harold N. Lovvorn*, Jenifer Westrup, Shaun Opperman, Scott Boyle, Genbin Shi, James Anderson, Elizabeth J. Perlman, Alan O. Perantoni, Marcia Wills, Mark De Caestecker

*Corresponding author for this work

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Wilms' tumors, or nephroblastomas, are thought to arise from abnormal postnatal retention and dysregulated differentiation of nephrogenic progenitor cells that originate as a condensed metanephric mesenchyme within embryonic kidneys. We have previously shown that the transcriptional regulator CITED1 (CBP/p300-interacting transactivators with glutamic acid [E ]/aspartic acid [D]-rich C-terminal domain) is expressed exclusively in these nephrogenic progenitor cells and is downregulated as they differentiate to form nephronic epithelia. In the current study, we show that CITED1 expression persists in blastemal cell populations of both experimental rat nephroblastomas and human Wilms' tumors, and that primary human Wilms' tumors presenting with disseminated disease show the highest level of CITED1 expression. Unlike the predominantly cytoplasmic subcellular localization of CITED1 in the normal developing kidney, CITED1 is clearly detectable in the nuclear compartment of Wilms' tumor blastema. These findings indicate that CITED1 is a marker of primitive blastema in Wilms' tumors and suggest that persistent expression and/or altered subcellular localization of CITED1 in the condensed metanephric mesenchyme could play a role in Wilms' tumor initiation and pathogenesis.

Original languageEnglish (US)
Pages (from-to)589-600
Number of pages12
JournalNeoplasia
Volume9
Issue number7
DOIs
StatePublished - Jul 2007

Keywords

  • CITED1
  • Metanephric mesenchyme
  • Nephroblastoma
  • Nuclear localization
  • Wilms' tumor

ASJC Scopus subject areas

  • Cancer Research

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  • Cite this

    Lovvorn, H. N., Westrup, J., Opperman, S., Boyle, S., Shi, G., Anderson, J., Perlman, E. J., Perantoni, A. O., Wills, M., & De Caestecker, M. (2007). CITED1 expression in wilms' tumor and embryonic kidney. Neoplasia, 9(7), 589-600. https://doi.org/10.1593/neo.07358