CLAN, a novel human CED-4-like gene

Jason S. Damiano*, Christian Stehlik, Frederick Pio, Adam Godzik, John C. Reed

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

57 Scopus citations

Abstract

Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-κB activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.

Original languageEnglish (US)
Pages (from-to)77-83
Number of pages7
JournalGenomics
Volume75
Issue number1-3
DOIs
StatePublished - Jul 1 2001

Keywords

  • Apoptosis
  • CARD
  • CED-4
  • Caspases
  • Cell death
  • LRR
  • NACHT

ASJC Scopus subject areas

  • Genetics

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