Class iii β-tubulin (TUBB3): More than a biomarker in solid tumors?

M. Mariani, S. Shahabi, S. Sieber, G. Scambia, C. Ferlini*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations

Abstract

Class III β -tubulin (TUBB3) is a prominent mechanism of drug resistance expressed in a variety of solid tumors and particularly in lung and ovarian cancer. In the classical view, TUBB3 expression and drug resistance have been linked, and together they have been associated with a perturbation in microtubule dynamics. In keeping with this observation, TUBB3 was associated with drug resistance only when chemotherapy included a taxane in its chemical composition. In this review, we demonstrate that the classical supposition about TUBB3 is not correct, and that instead TUBB3 expression is linked to drug resistance as a complex survival mechanism activated by microenvironmental conditions such as poor nutrient supply and hypoxia.

Original languageEnglish (US)
Pages (from-to)726-731
Number of pages6
JournalCurrent Molecular Medicine
Volume11
Issue number9
DOIs
StatePublished - Dec 2011

Keywords

  • Biomarkers
  • Drug-resistance
  • Poor outcome
  • Tubulin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology

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