Classic Gout in Hageman Factor (Factor XII) Deficiency

David Green*, Christiane L. Arsever, Kenneth A. Grumet, Oscar D. Ratnoff

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


A 62-year-old man with a typical history of gout was admitted to the hospital with left-sided hemiplegia. His serum uric acid level was 10.3 mg/dL, his partial thromboplastin time was 198 s, and his Hageman factor (factor XII) coagulant activity and antigen were less than 1% of normal. Aspiration of synovial fluid from his inflamed knee disclosed urate crystals and abundant leukocytes but an absence of Hageman factor antigen. The presence of acute gouty arthritis in a patient with Hageman trait challenges the role of Hageman factor in the pathogenesis of gouty arthropathy.

Original languageEnglish (US)
Pages (from-to)1556-1557
Number of pages2
JournalArchives of Internal Medicine
Issue number8
StatePublished - Aug 1982

ASJC Scopus subject areas

  • Internal Medicine

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