Clear cell papillary renal cell carcinoma: a chromosomal microarray analysis of two cases using a novel Molecular Inversion Probe (MIP) technology

Borislav A. Alexiev, Ying S. Zou

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Chromosomal microarray analysis using novel Molecular Inversion Probe (MIP) technology demonstrated 2,570 kb copy neutral LOH of 10q11.22 in two clear cell papillary renal cell carcinomas. In addition, one of the tumors had a big 29,784 kb deletion of 13q11-q14.2. There were two variants of unknown significance, a 2,509 kb gain of Xp22.33 and a 257 kb homozygous deletion of 8p11.22. The somatic mutation panel containing 74 mutations in nine genes did not reveal any mutations. Besides identification of submicroscopic duplications or deletions, SNP microarrays can reveal abnormal allelic imbalances including LOH and copy neutral LOH, which cannot be recognized by chromosome, FISH, and non-SNP microarray arrays. To the best of our knowledge, this is the first study demonstrating copy neutral LOH of 10q11.22 in clear cell papillary renal cell carcinomas using the new MIP SNP OncoScan FFPE Assay Kit on formalin-fixed paraffin-embedded tumor samples.

Original languageEnglish (US)
Pages (from-to)1049-1053
Number of pages5
JournalPathology, research and practice
Volume210
Issue number12
DOIs
StatePublished - Dec 1 2014

Keywords

  • Molecular Inversion Probe
  • Renal carcinoma

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Clear cell papillary renal cell carcinoma: a chromosomal microarray analysis of two cases using a novel Molecular Inversion Probe (MIP) technology'. Together they form a unique fingerprint.

Cite this