Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases

Krainc Dimitri

doi:10.1001/archneurol.2010.40

Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases

Krainc Dimitri^*

^*Corresponding author for this work

Neurology

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Accumulation and aggregation of disease-causing proteins is a hallmark of several neurodegenerative disorders such as Parkinson, Alzheimer, and Huntington diseases. One of the main goals of research in neurodegenerative disorders has been to improve clearance of these accumulated proteins. Using the example of Huntington disease, I discuss strategies to selectively activate cellular degradation machinery to improve clearance of the mutant protein and to identify therapeutic targets for the treatment of Huntington disease and related neurodegenerative disorders.

Original language	English (US)
Pages (from-to)	388-392
Number of pages	5
Journal	Archives of Neurology
Volume	67
Issue number	4
DOIs	https://doi.org/10.1001/archneurol.2010.40
State	Published - Apr 2010

ASJC Scopus subject areas

Arts and Humanities (miscellaneous)
Clinical Neurology

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10.1001/archneurol.2010.40

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abstract = "Accumulation and aggregation of disease-causing proteins is a hallmark of several neurodegenerative disorders such as Parkinson, Alzheimer, and Huntington diseases. One of the main goals of research in neurodegenerative disorders has been to improve clearance of these accumulated proteins. Using the example of Huntington disease, I discuss strategies to selectively activate cellular degradation machinery to improve clearance of the mutant protein and to identify therapeutic targets for the treatment of Huntington disease and related neurodegenerative disorders.",

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AB - Accumulation and aggregation of disease-causing proteins is a hallmark of several neurodegenerative disorders such as Parkinson, Alzheimer, and Huntington diseases. One of the main goals of research in neurodegenerative disorders has been to improve clearance of these accumulated proteins. Using the example of Huntington disease, I discuss strategies to selectively activate cellular degradation machinery to improve clearance of the mutant protein and to identify therapeutic targets for the treatment of Huntington disease and related neurodegenerative disorders.

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Clearance of mutant proteins as a therapeutic target in neurodegenerative diseases

Abstract

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