Abstract
Introduction: Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation. Methods: Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPA Aβ+ and PPA Aβ− ), an imaging biomarker of underlying Alzheimer's disease. Results: Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPA Aβ+ . The PPA Aβ+ group also showed greater decline in performance on most language tasks. There was no obligatory relationship between the logopenic PPA variant and amyloid status. Effect sizes from quantitative MRI data were more robust than neuropsychological metrics. Discussion: Preferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non–Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 543-552 |
| Number of pages | 10 |
| Journal | Alzheimer's and Dementia |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2019 |
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Keywords
- Amyloid PET
- Biomarker
- FreeSurfer
- Frontotemporal dementia
- Frontotemporal lobar degeneration
- Neuropsychology
- Primary progressive aphasia
- Progression
- Volumetric MRI
ASJC Scopus subject areas
- Epidemiology
- Health Policy
- Developmental Neuroscience
- Clinical Neurology
- Geriatrics and Gerontology
- Cellular and Molecular Neuroscience
- Psychiatry and Mental health
Cite this
}
Clinical and cortical decline in the aphasic variant of Alzheimer's disease. / Rogalski, Emily; Sridhar, Jaiashre; Martersteck, Adam; Rader, Benjamin; Cobia, Derin; Arora, Anupa K.; Fought, Angela J.; Bigio, Eileen H; Weintraub, Sandra; Mesulam, Marek-Marsel; Rademaker, Alfred W.
In: Alzheimer's and Dementia, Vol. 15, No. 4, 01.04.2019, p. 543-552.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical and cortical decline in the aphasic variant of Alzheimer's disease
AU - Rogalski, Emily
AU - Sridhar, Jaiashre
AU - Martersteck, Adam
AU - Rader, Benjamin
AU - Cobia, Derin
AU - Arora, Anupa K.
AU - Fought, Angela J.
AU - Bigio, Eileen H
AU - Weintraub, Sandra
AU - Mesulam, Marek-Marsel
AU - Rademaker, Alfred W
PY - 2019/4/1
Y1 - 2019/4/1
N2 - Introduction: Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation. Methods: Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPA Aβ+ and PPA Aβ− ), an imaging biomarker of underlying Alzheimer's disease. Results: Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPA Aβ+ . The PPA Aβ+ group also showed greater decline in performance on most language tasks. There was no obligatory relationship between the logopenic PPA variant and amyloid status. Effect sizes from quantitative MRI data were more robust than neuropsychological metrics. Discussion: Preferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non–Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials.
AB - Introduction: Primary progressive aphasia (PPA) displays variable progression trajectories that require further elucidation. Methods: Longitudinal quantitation of atrophy and language over 12 months was completed for PPA patients with and without positive amyloid PET (PPA Aβ+ and PPA Aβ− ), an imaging biomarker of underlying Alzheimer's disease. Results: Over 12 months, both PPA groups showed significantly greater cortical atrophy rates in the left versus right hemisphere, with a more widespread pattern in PPA Aβ+ . The PPA Aβ+ group also showed greater decline in performance on most language tasks. There was no obligatory relationship between the logopenic PPA variant and amyloid status. Effect sizes from quantitative MRI data were more robust than neuropsychological metrics. Discussion: Preferential language network neurodegeneration is present in PPA irrespective of amyloid status. Clinical and anatomical progression appears to differ for PPA due to Alzheimer's disease versus non–Alzheimer's disease neuropathology, a distinction that may help to inform prognosis and the design of intervention trials.
KW - Amyloid PET
KW - Biomarker
KW - FreeSurfer
KW - Frontotemporal dementia
KW - Frontotemporal lobar degeneration
KW - Neuropsychology
KW - Primary progressive aphasia
KW - Progression
KW - Volumetric MRI
UR - http://www.scopus.com/inward/record.url?scp=85061268956&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85061268956&partnerID=8YFLogxK
U2 - 10.1016/j.jalz.2018.12.003
DO - 10.1016/j.jalz.2018.12.003
M3 - Article
C2 - 30765195
AN - SCOPUS:85061268956
VL - 15
SP - 543
EP - 552
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
SN - 1552-5260
IS - 4
ER -