Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients

William J. Muller; Myron J. Levin; Young Kyoo Shin; Christine Robinson; Ralph Quinones; Janet Malcolm; Elaine Hild; Dexiang Gao; Roger Giller

doi:10.1086/498151

Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients

William J. Muller^*, Myron J. Levin, Young Kyoo Shin, Christine Robinson, Ralph Quinones, Janet Malcolm, Elaine Hild, Dexiang Gao, Roger Giller

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

69 Scopus citations

Abstract

Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.

Original language	English (US)
Pages (from-to)	1812-1816
Number of pages	5
Journal	Clinical Infectious Diseases
Volume	41
Issue number	12
DOIs	https://doi.org/10.1086/498151
State	Published - Dec 15 2005

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1086/498151

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Muller, William J. ; Levin, Myron J. ; Shin, Young Kyoo ; Robinson, Christine ; Quinones, Ralph ; Malcolm, Janet ; Hild, Elaine ; Gao, Dexiang ; Giller, Roger. / Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. In: Clinical Infectious Diseases. 2005 ; Vol. 41, No. 12. pp. 1812-1816.

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Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. / Muller, William J.; Levin, Myron J.; Shin, Young Kyoo; Robinson, Christine; Quinones, Ralph; Malcolm, Janet; Hild, Elaine; Gao, Dexiang; Giller, Roger.

In: Clinical Infectious Diseases, Vol. 41, No. 12, 15.12.2005, p. 1812-1816.

Research output: Contribution to journal › Article › peer-review

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