Abstract
Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1812-1816 |
| Number of pages | 5 |
| Journal | Clinical Infectious Diseases |
| Volume | 41 |
| Issue number | 12 |
| DOIs | |
| State | Published - Dec 15 2005 |
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ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
Cite this
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Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. / Muller, William J.; Levin, Myron J.; Shin, Young Kyoo; Robinson, Christine; Quinones, Ralph; Malcolm, Janet; Hild, Elaine; Gao, Dexiang; Giller, Roger.
In: Clinical Infectious Diseases, Vol. 41, No. 12, 15.12.2005, p. 1812-1816.Research output: Contribution to journal › Article
TY - JOUR
T1 - Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients
AU - Muller, William J.
AU - Levin, Myron J.
AU - Shin, Young Kyoo
AU - Robinson, Christine
AU - Quinones, Ralph
AU - Malcolm, Janet
AU - Hild, Elaine
AU - Gao, Dexiang
AU - Giller, Roger
PY - 2005/12/15
Y1 - 2005/12/15
N2 - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.
AB - Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.
UR - http://www.scopus.com/inward/record.url?scp=28744445050&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28744445050&partnerID=8YFLogxK
U2 - 10.1086/498151
DO - 10.1086/498151
M3 - Article
C2 - 16288409
AN - SCOPUS:28744445050
VL - 41
SP - 1812
EP - 1816
JO - Clinical Infectious Diseases
JF - Clinical Infectious Diseases
SN - 1058-4838
IS - 12
ER -