Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients

William J. Muller*, Myron J. Levin, Young Kyoo Shin, Christine Robinson, Ralph Quinones, Janet Malcolm, Elaine Hild, Dexiang Gao, Roger Giller

*Corresponding author for this work

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Post-hematopoietic stem cell transplantation (HSCT) adenovirus infections were identified in 31 of 204 consecutive pediatric HSCT patients, 18 of whom had severe manifestations of infection. Cidofovir treatment led to clinical improvement in 8 of 10 patients with severe infection and to virologic clearance in 9 patients. In vitro susceptibility to cidofovir was demonstrated in 12 clinical adenovirus isolates. Cidofovir is a promising treatment option for this population.

Original languageEnglish (US)
Pages (from-to)1812-1816
Number of pages5
JournalClinical Infectious Diseases
Volume41
Issue number12
DOIs
StatePublished - Dec 15 2005

Fingerprint

Adenoviridae Infections
Hematopoietic Stem Cells
Hematopoietic Stem Cell Transplantation
Pediatrics
Transplants
Infection
Adenoviridae
Therapeutics
Population
In Vitro Techniques
cidofovir
Transplant Recipients

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

Cite this

Muller, William J. ; Levin, Myron J. ; Shin, Young Kyoo ; Robinson, Christine ; Quinones, Ralph ; Malcolm, Janet ; Hild, Elaine ; Gao, Dexiang ; Giller, Roger. / Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. In: Clinical Infectious Diseases. 2005 ; Vol. 41, No. 12. pp. 1812-1816.
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Clinical and in vitro evaluation of cidofovir for treatment of adenovirus infection in pediatric hematopoietic stem cell transplant recipients. / Muller, William J.; Levin, Myron J.; Shin, Young Kyoo; Robinson, Christine; Quinones, Ralph; Malcolm, Janet; Hild, Elaine; Gao, Dexiang; Giller, Roger.

In: Clinical Infectious Diseases, Vol. 41, No. 12, 15.12.2005, p. 1812-1816.

Research output: Contribution to journalArticle

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AU - Giller, Roger

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