Clinical and pathological features of hereditary prostate cancer

David W. Keetch*, Peter A. Humphrey, Deborah S. Smith, David Stahl, William J. Catalona

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations


Purpose: We determined whether the clinical and pathological features of hereditary prostate cancer differ from those of sporadic prostate cancer. Materials and Methods: We compared the clinical and pathological features of radical prostatectomy specimens from 50 men with and 50 without a family history of prostate cancer who were matched for age and date of surgery. Results: Median serum prostate specific antigen concentration was not significantly different in the 2 groups. Mean Gleason score plus or minus standard deviation in the 50 men with sporadic prostate cancer was 6.2 ± 1 compared to 5.6 ± 0.9 in those with hereditary disease (p = 0.008). Of the 50 hereditary and 50 sporadic prostate cancers 35 (70%) and 33 (66%), respectively, were pathologically organ confined (p = 0.69). Median percentage of carcinoma within the gland (determined morphometrically) in men with hereditary disease was 11.4 ± 8.3 compared to 10.9 ± 8.9 for those with sporadic cancer (p = 0.63). Conclusions: In our study population hereditary prostate cancers have significantly lower Gleason scores compared to sporadic carcinomas. Otherwise, there appear to be no substantial clinical or pathological differences.

Original languageEnglish (US)
Pages (from-to)1841-1843
Number of pages3
JournalJournal of Urology
Issue number6
StatePublished - Jun 1996


  • hereditary diseases
  • prostatic neoplasms

ASJC Scopus subject areas

  • Urology


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