TY - JOUR
T1 - Clinical and serologic follow-up of four children and five adults with bird-fancier's lung
AU - Grammer, Leslie C.
AU - Roberts, Mary
AU - Lerner, Cynthia
AU - Patterson, Roy
N1 - Funding Information:
From the Section of Occupational Medicine and Allergy-Immunology, Department of Medicine, and *Department of Pe-diatrics, Northwestern University Medical School, Chicago, Ill. Supported by the Ernest S. Bazley Grant and United States Public Health Service Asthma and Allergic Diseases Center Grant AI 11403. Received for publication Aug. 8, 1989. Revised Oct. 24, 1989. Accepted Oct. 25, 1989. Reprint requests: Leslie Grammer, MD, Northwestern University Medical School, 303 E. Chicago Ave., Chicago, IL 60611. 1/1/17I3a
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 1990/3
Y1 - 1990/3
N2 - We report the clinical and serologic findings in four children and five adults with chronic avian hypersensitivity pneumonitis. All subjects were treated with corticosteroids and bird exposure was reduced or eliminated. After a variable period, ranging from 6 months to 10 years, their clinical and serologic findings were reassessed. In terms of symptomatology, chest findings, and pulmonary functions, all four children improved and four adults improved, whereas one adult had a progressive clinical deterioration, ultimately resulting in her death 5 years later. In terms of serologic data, precipitating antibody tended to persist, and antibody to avian antigens, as determined by ELISA, remained positive, although the titer declined. We conclude that, while serologic positivity remains, the prognosis for children and adults with chronic avian hypersensitivity pneumonitis is very good, provided that irreversible damage has not already occurred at the time of diagnosis.
AB - We report the clinical and serologic findings in four children and five adults with chronic avian hypersensitivity pneumonitis. All subjects were treated with corticosteroids and bird exposure was reduced or eliminated. After a variable period, ranging from 6 months to 10 years, their clinical and serologic findings were reassessed. In terms of symptomatology, chest findings, and pulmonary functions, all four children improved and four adults improved, whereas one adult had a progressive clinical deterioration, ultimately resulting in her death 5 years later. In terms of serologic data, precipitating antibody tended to persist, and antibody to avian antigens, as determined by ELISA, remained positive, although the titer declined. We conclude that, while serologic positivity remains, the prognosis for children and adults with chronic avian hypersensitivity pneumonitis is very good, provided that irreversible damage has not already occurred at the time of diagnosis.
UR - http://www.scopus.com/inward/record.url?scp=0025349291&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025349291&partnerID=8YFLogxK
U2 - 10.1016/0091-6749(90)90107-F
DO - 10.1016/0091-6749(90)90107-F
M3 - Article
C2 - 2107243
AN - SCOPUS:0025349291
VL - 85
SP - 655
EP - 660
JO - Journal of Allergy and Clinical Immunology
JF - Journal of Allergy and Clinical Immunology
SN - 0091-6749
IS - 3
ER -