Clinical Application of Time in Range and Other Metrics

Grazia Aleppo*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Time in range (TIR) and other continuous glucose monitoring (CGM)-derived metrics have been standardized in international consensus conferences. TIR correlates closely with A1C; a TIR of 70% correlates to an A1C of 6.7–7%. Evidence is emerging on the association of TIR with long-term diabetes complications, and each 10% increase in TIR shows a substantial decrease in risk for long-term complications. Application of TIR to clinical practice can be easily done with a stepped approach to the analysis and interpretation of CGM-derived metrics and the ambulatory glucose profile report. Clinician education and partnership with patients are crucial for successful implementation of TIR and all CGM-derived metrics in clinical practice.

Original languageEnglish (US)
Pages (from-to)109-118
Number of pages10
JournalDiabetes Spectrum
Issue number2
StatePublished - May 1 2021

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism


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