Abstract
B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once considered incurable. Evaluating patients with primary immunodeficiency diseases (PID)/inborn errors of immunity (IEI) that primarily affect B cells, offers us an opportunity to further our understanding of how B cells develop, mature, function and, in certain instances, cause further disease. In this review we provide a brief compendium of IEI that principally affect B cells at defined stages of their developmental pathway, and also attempt to offer some educated viewpoints on how the management of these disorders could evolve over the years.
Original language | English (US) |
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Article number | 3353 |
Journal | Cells |
Volume | 11 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2022 |
Funding
We are very grateful to the Jeffrey Modell Foundation for their philanthropic support. The APC was funded by the Jeffrey Modell Foundation.
Keywords
- B cells
- humoral immunity
- immunodeficiency
- inborn errors of immunity
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology