Clinical Aspects of B Cell Immunodeficiencies: The Past, the Present and the Future

Aisha Ahmed, Elizabeth Lippner, Aaruni Khanolkar*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


B cells and antibodies are indispensable for host immunity. Our understanding of the mechanistic processes that underpin how B cells operate has left an indelible mark on the field of clinical pathology, and recently has also dramatically reshaped the therapeutic landscape of diseases that were once considered incurable. Evaluating patients with primary immunodeficiency diseases (PID)/inborn errors of immunity (IEI) that primarily affect B cells, offers us an opportunity to further our understanding of how B cells develop, mature, function and, in certain instances, cause further disease. In this review we provide a brief compendium of IEI that principally affect B cells at defined stages of their developmental pathway, and also attempt to offer some educated viewpoints on how the management of these disorders could evolve over the years.

Original languageEnglish (US)
Article number3353
Issue number21
StatePublished - Nov 2022


  • B cells
  • humoral immunity
  • immunodeficiency
  • inborn errors of immunity

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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