Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort

Mariangelí Arroyo-Ávila, Yesenia Santiago-Casas, Gerald McGwin, Ryan S. Cantor, Michelle Petri, Rosalind Ramsey-Goldman, John D. Reveille, Robert P. Kimberly, Graciela S. Alarcón, Luis M. Vilá*, Elizabeth E. Brown

*Corresponding author for this work

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The aim of this study was to determine the association of anti-Sm antibodies with clinical manifestations, comorbidities, and disease damage in a large multi-ethnic SLE cohort. SLE patients (per American College of Rheumatology criteria), age ≥16 years, disease duration ≤10 years at enrollment, and defined ethnicity (African American, Hispanic or Caucasian), from a longitudinal US cohort were studied. Socioeconomic-demographic features, cumulative clinical manifestations, comorbidities, and disease damage (as per the Systemic Lupus International Collaborating Clinics Damage Index [SDI]) were determined. The association of anti-Sm antibodies with clinical features was examined using multivariable logistic regression analyses adjusting for age, gender, ethnicity, disease duration, level of education, health insurance, and smoking. A total of 2322 SLE patients were studied. The mean (standard deviation, SD) age at diagnosis was 34.4 (12.8) years and the mean (SD) disease duration was 9.0 (7.9) years; 2127 (91.6 %) were women. Anti-Sm antibodies were present in 579 (24.9 %) patients. In the multivariable analysis, anti-Sm antibodies were significantly associated with serositis, renal involvement, psychosis, vasculitis, Raynaud’s phenomenon, hemolytic anemia, leukopenia, lymphopenia, and arterial hypertension. No significant association was found for damage accrual. In this cohort of SLE patients, anti-Sm antibodies were associated with several clinical features including serious manifestations such as renal, neurologic, and hematologic disorders as well as vasculitis.

Original languageEnglish (US)
Pages (from-to)1217-1223
Number of pages7
JournalClinical Rheumatology
Volume34
Issue number7
DOIs
StatePublished - Jul 23 2015

Keywords

  • Anti-Smith antibodies
  • Clinical manifestations
  • Disease damage
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology

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    Arroyo-Ávila, M., Santiago-Casas, Y., McGwin, G., Cantor, R. S., Petri, M., Ramsey-Goldman, R., Reveille, J. D., Kimberly, R. P., Alarcón, G. S., Vilá, L. M., & Brown, E. E. (2015). Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clinical Rheumatology, 34(7), 1217-1223. https://doi.org/10.1007/s10067-015-2941-y