Clinical, biochemical, and ovarian morphologic features in women with acanthosis nigricans and masculinization

Andrea Dunaif*, Andrew R. Hoffman, Robert E. Scully, Jeffrey S. Flier, Christopher Longcope, Leonard J. Levy, William F. Crowley

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

65 Scopus citations

Abstract

Nine women with acanthosis nigricans and masculinization, who did not appear to have any of the reported syndromes associated with acanthosis nigricans, were studied to characterize the clinical, biochemical, and ovarian morphologic features of their disorders. These patients had the clinical and biochemical profiles of polycystic ovarian disease. All acanthosis nigricans subjects had significant insulin resistance when insulin binding to both circulating monocytes and erythrocytes was compared to the control subjects. Microscopic examination of the ovaries revealed no evidence of recent normal ovulation, sclerosis of the ovarian cortex, follicle cysts, and stromal hyperthecosis. The authors conclude that ovarian stromal hyperthecosis and insulin resistance are consistent findings in the present type of patient. This study provides further evidence supporting a relationship between insulin resistance and human ovarian function.

Original languageEnglish (US)
Pages (from-to)545-552
Number of pages8
JournalObstetrics and gynecology
Volume66
Issue number4
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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