TY - JOUR
T1 - Clinical Case Panel
T2 - Treatment Alternatives for Inoperable Hepatocellular Carcinoma
AU - Toesca, Diego A.S.
AU - Barry, Aisling
AU - Sapisochin, Gonzalo
AU - Beecroft, Robert
AU - Dawson, Laura
AU - Owen, Dawn
AU - Mouli, Samdeep
AU - Lewandowski, Robert
AU - Salem, Riad
AU - Chang, Daniel T.
N1 - Funding Information:
Daniel T. Chang, MD has stock on ViewRay, Inc and received honoraria and research funding from Varian Medical Systems, Inc. For the remaining authors, none were declared.
Publisher Copyright:
© 2018
PY - 2018/10
Y1 - 2018/10
N2 - Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. For those cases not amenable for resection, a variety of local treatment modalities are available, such as image-guided ablative procedures, transarterial chemoembolization, and radioembolization, as well as external beam radiation. HCC presentation can vary considerably in size, number, and location of lesions. The management of inoperable HCC is, therefore, quite complex, and there is a lack of consensus on the best local treatment modality for each type tumor presentation. Here, we present 4 clinical case scenarios representative of commonly seen cases in the clinical setting, with different therapeutic perspectives from institutions with high expertise in the management of HCC.
AB - Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. For those cases not amenable for resection, a variety of local treatment modalities are available, such as image-guided ablative procedures, transarterial chemoembolization, and radioembolization, as well as external beam radiation. HCC presentation can vary considerably in size, number, and location of lesions. The management of inoperable HCC is, therefore, quite complex, and there is a lack of consensus on the best local treatment modality for each type tumor presentation. Here, we present 4 clinical case scenarios representative of commonly seen cases in the clinical setting, with different therapeutic perspectives from institutions with high expertise in the management of HCC.
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U2 - 10.1016/j.semradonc.2018.08.001
DO - 10.1016/j.semradonc.2018.08.001
M3 - Review article
C2 - 30309640
AN - SCOPUS:85053624873
SN - 1053-4296
VL - 28
SP - 295
EP - 308
JO - Seminars in Radiation Oncology
JF - Seminars in Radiation Oncology
IS - 4
ER -
