Clinical Case Panel: Treatment Alternatives for Inoperable Hepatocellular Carcinoma

Diego A.S. Toesca, Aisling Barry, Gonzalo Sapisochin, Robert Beecroft, Laura Dawson, Dawn Owen, Samdeep Mouli, Robert Lewandowski, Riad Salem, Daniel T. Chang*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

3 Scopus citations


Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. For those cases not amenable for resection, a variety of local treatment modalities are available, such as image-guided ablative procedures, transarterial chemoembolization, and radioembolization, as well as external beam radiation. HCC presentation can vary considerably in size, number, and location of lesions. The management of inoperable HCC is, therefore, quite complex, and there is a lack of consensus on the best local treatment modality for each type tumor presentation. Here, we present 4 clinical case scenarios representative of commonly seen cases in the clinical setting, with different therapeutic perspectives from institutions with high expertise in the management of HCC.

Original languageEnglish (US)
Pages (from-to)295-308
Number of pages14
JournalSeminars in Radiation Oncology
Issue number4
StatePublished - Oct 2018

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research


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