Clinical Case Panel: Treatment Alternatives for Inoperable Hepatocellular Carcinoma

Diego A.S. Toesca, Aisling Barry, Gonzalo Sapisochin, Robert Beecroft, Laura Dawson, Dawn Owen, Samdeep K Mouli, Robert J Lewandowski, Riad Salem, Daniel T. Chang*

*Corresponding author for this work

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. For those cases not amenable for resection, a variety of local treatment modalities are available, such as image-guided ablative procedures, transarterial chemoembolization, and radioembolization, as well as external beam radiation. HCC presentation can vary considerably in size, number, and location of lesions. The management of inoperable HCC is, therefore, quite complex, and there is a lack of consensus on the best local treatment modality for each type tumor presentation. Here, we present 4 clinical case scenarios representative of commonly seen cases in the clinical setting, with different therapeutic perspectives from institutions with high expertise in the management of HCC.

Original languageEnglish (US)
Pages (from-to)295-308
Number of pages14
JournalSeminars in Radiation Oncology
Volume28
Issue number4
DOIs
StatePublished - Oct 1 2018

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Hepatocellular Carcinoma
Liver Transplantation
Waiting Lists
Liver
Therapeutics
Radiation
Neoplasms

ASJC Scopus subject areas

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

Cite this

Toesca, D. A. S., Barry, A., Sapisochin, G., Beecroft, R., Dawson, L., Owen, D., ... Chang, D. T. (2018). Clinical Case Panel: Treatment Alternatives for Inoperable Hepatocellular Carcinoma. Seminars in Radiation Oncology, 28(4), 295-308. https://doi.org/10.1016/j.semradonc.2018.08.001
Toesca, Diego A.S. ; Barry, Aisling ; Sapisochin, Gonzalo ; Beecroft, Robert ; Dawson, Laura ; Owen, Dawn ; Mouli, Samdeep K ; Lewandowski, Robert J ; Salem, Riad ; Chang, Daniel T. / Clinical Case Panel : Treatment Alternatives for Inoperable Hepatocellular Carcinoma. In: Seminars in Radiation Oncology. 2018 ; Vol. 28, No. 4. pp. 295-308.
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Clinical Case Panel : Treatment Alternatives for Inoperable Hepatocellular Carcinoma. / Toesca, Diego A.S.; Barry, Aisling; Sapisochin, Gonzalo; Beecroft, Robert; Dawson, Laura; Owen, Dawn; Mouli, Samdeep K; Lewandowski, Robert J; Salem, Riad; Chang, Daniel T.

In: Seminars in Radiation Oncology, Vol. 28, No. 4, 01.10.2018, p. 295-308.

Research output: Contribution to journalReview article

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T2 - Treatment Alternatives for Inoperable Hepatocellular Carcinoma

AU - Toesca, Diego A.S.

AU - Barry, Aisling

AU - Sapisochin, Gonzalo

AU - Beecroft, Robert

AU - Dawson, Laura

AU - Owen, Dawn

AU - Mouli, Samdeep K

AU - Lewandowski, Robert J

AU - Salem, Riad

AU - Chang, Daniel T.

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AB - Surgical resection or liver transplantation offers the best chance of cure for patients with hepatocellular carcinoma (HCC). Unfortunately, most patients are not good candidates for liver resection due to locally advanced disease or compromised liver function. Moreover, liver transplantation waiting lists are long. For those cases not amenable for resection, a variety of local treatment modalities are available, such as image-guided ablative procedures, transarterial chemoembolization, and radioembolization, as well as external beam radiation. HCC presentation can vary considerably in size, number, and location of lesions. The management of inoperable HCC is, therefore, quite complex, and there is a lack of consensus on the best local treatment modality for each type tumor presentation. Here, we present 4 clinical case scenarios representative of commonly seen cases in the clinical setting, with different therapeutic perspectives from institutions with high expertise in the management of HCC.

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