Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians

Patricia A. Agaba, Eunice Digin, Rahila Makai, Labake Apena, Oche O. Agbaji, John A. Idoko, Rob Murphy, Phyllis Kanki

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Introduction: Human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) is a chief cause of death in sub-Saharan Africa. In this study, the clinical characteristics and predictors of mortality among hospitalized HIV infected adult Nigerians are reported. Methodology: The records of 354 patients were reviewed for demographic and clinical characteristics. Predictors of mortality using logistic regression in a retrospective study were also reviewed. Results: A total of 109 (30.8%) males and 245 (69.2%) females participated in the study. The mean age of all participants was 35 ± 8 years. Median baseline CD4 cell counts and viral load were 91 cells/mm3 and 63,438 copies/ml respectively. There was a total of 123 (34.8%) deaths while 231 (65.2%) patients were discharged home. Tuberculosis (TB) was the most common diagnosis on admission as well as the leading cause of death. Among all subjects, only male gender (adjusted odds ratio [AOR] 4.67, 95% confidence interval [CI]: 2.63-8.29); CD4 cell count ≤ 200 cells/mm3 (AOR 5.28, 95% CI: 2.99-9.31); length of hospital stay < 3 days (AOR 4.77, 95% CI: 1.35-16.86); and age ≥ 35 years (AOR 2.43, 95% CI: 1.41-4.19) were predictive of death. Conclusion: These findings illustrate the need for early diagnosis of HIV infection, appropriate treatment and prevention of opportunistic infections, and improved access to highly active antiretroviral therapy (HAART).

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalJournal of Infection in Developing Countries
Volume5
Issue number5
DOIs
StatePublished - May 2011

Keywords

  • Characteristics
  • HIV infected
  • Hospitalized
  • Mortality
  • Nigerians

ASJC Scopus subject areas

  • Parasitology
  • Microbiology
  • Infectious Diseases
  • Virology

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