Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali

B. Kone; Y. S. Sarro; M. Maiga; M. Sanogo; A. M. Somboro; B. Diarra; A. C.G. Togo; N. Coulibaly; B. P.P. Dembele; D. Goita; B. Baya; A. Kone; S. Diabaté; M. A. Polis; M. Belson; S. Dao; S. Orsega; C. J. Achenbach; R. L. Murphy; S. Diallo; S. Siddiqui

doi:10.1017/S0950268817003090

Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali

B. Kone, Y. S. Sarro^*, M. Maiga, M. Sanogo, A. M. Somboro, B. Diarra, A. C.G. Togo, N. Coulibaly, B. P.P. Dembele, D. Goita, B. Baya, A. Kone, S. Diabaté, M. A. Polis, M. Belson, S. Dao, S. Orsega, C. J. Achenbach, R. L. Murphy, S. DialloS. Siddiqui

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The global spread of non-tuberculous mycobacteria (NTM) may be due to HIV/AIDS and other environmental factors. The symptoms of NTM and tuberculosis (TB) disease are indistinguishable, but their treatments are different. Lack of research on the epidemiology of NTM infections has led to underestimation of its prevalence within TB endemic countries. This study was designed to determine the prevalence and clinical characteristics of pulmonary NTM in Bamako. A cross-sectional study which include 439 suspected cases of pulmonary TB. From 2006 to 2013 a total of 332 (76%) were confirmed to have sputum culture positive for mycobacteria. The prevalence of NTM infection was 9.3% of our study population and 12.3% of culture positive patients. The seroprevalence of HIV in NTM group was 17.1%. Patients who weighed <55 kg and had TB symptoms other than cough were also significantly more likely to have disease due to NTM as compared to those with TB disease who were significantly more likely to have cough and weigh more than 55 kg (OR 0.05 (CI 0.02-0.13) and OR 0.32 (CI 0.11-0.93) respectively). NTM disease burden in Bamako was substantial and diagnostic algorithms for pulmonary disease in TB endemic countries should consider the impact of NTM.

Original language	English (US)
Pages (from-to)	354-358
Number of pages	5
Journal	Epidemiology and Infection
Volume	146
Issue number	3
DOIs	https://doi.org/10.1017/S0950268817003090
State	Published - Feb 1 2018

Keywords

Bamako
clinical characteristics
non-tuberculous mycobacteria
tuberculosis

ASJC Scopus subject areas

Epidemiology
Infectious Diseases

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1017/S0950268817003090

Cite this

Kone, B., Sarro, Y. S., Maiga, M., Sanogo, M., Somboro, A. M., Diarra, B., Togo, A. C. G., Coulibaly, N., Dembele, B. P. P., Goita, D., Baya, B., Kone, A., Diabaté, S., Polis, M. A., Belson, M., Dao, S., Orsega, S., Achenbach, C. J., Murphy, R. L., ... Siddiqui, S. (2018). Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali. Epidemiology and Infection, 146(3), 354-358. https://doi.org/10.1017/S0950268817003090

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title = "Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali",

abstract = "The global spread of non-tuberculous mycobacteria (NTM) may be due to HIV/AIDS and other environmental factors. The symptoms of NTM and tuberculosis (TB) disease are indistinguishable, but their treatments are different. Lack of research on the epidemiology of NTM infections has led to underestimation of its prevalence within TB endemic countries. This study was designed to determine the prevalence and clinical characteristics of pulmonary NTM in Bamako. A cross-sectional study which include 439 suspected cases of pulmonary TB. From 2006 to 2013 a total of 332 (76%) were confirmed to have sputum culture positive for mycobacteria. The prevalence of NTM infection was 9.3% of our study population and 12.3% of culture positive patients. The seroprevalence of HIV in NTM group was 17.1%. Patients who weighed <55 kg and had TB symptoms other than cough were also significantly more likely to have disease due to NTM as compared to those with TB disease who were significantly more likely to have cough and weigh more than 55 kg (OR 0.05 (CI 0.02-0.13) and OR 0.32 (CI 0.11-0.93) respectively). NTM disease burden in Bamako was substantial and diagnostic algorithms for pulmonary disease in TB endemic countries should consider the impact of NTM.",

keywords = "Bamako, clinical characteristics, non-tuberculous mycobacteria, tuberculosis",

author = "B. Kone and Sarro, {Y. S.} and M. Maiga and M. Sanogo and Somboro, {A. M.} and B. Diarra and Togo, {A. C.G.} and N. Coulibaly and Dembele, {B. P.P.} and D. Goita and B. Baya and A. Kone and S. Diabat{\'e} and Polis, {M. A.} and M. Belson and S. Dao and S. Orsega and Achenbach, {C. J.} and Murphy, {R. L.} and S. Diallo and S. Siddiqui",

note = "Funding Information: The authors would like to acknowledge all SEREFO/ UCRC staff, laboratory and clinical who contributed to patient recruitment, sample processing and data collection. The authors are immensely grateful to the volunteers who participated in the study. This work was supported by the National Institutes of Health (R01AI110386, D43TW010350 and D71 TW010428-01A1). Publisher Copyright: Copyright {\textcopyright} 2018 Cambridge University Press.",

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doi = "10.1017/S0950268817003090",

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Kone, B, Sarro, YS, Maiga, M, Sanogo, M, Somboro, AM, Diarra, B, Togo, ACG, Coulibaly, N, Dembele, BPP, Goita, D, Baya, B, Kone, A, Diabaté, S, Polis, MA, Belson, M, Dao, S, Orsega, S, Achenbach, CJ , Murphy, RL, Diallo, S & Siddiqui, S 2018, 'Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali', Epidemiology and Infection, vol. 146, no. 3, pp. 354-358. https://doi.org/10.1017/S0950268817003090

TY - JOUR

T1 - Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali

AU - Kone, B.

AU - Sarro, Y. S.

AU - Maiga, M.

AU - Sanogo, M.

AU - Somboro, A. M.

AU - Diarra, B.

AU - Togo, A. C.G.

AU - Coulibaly, N.

AU - Dembele, B. P.P.

AU - Goita, D.

AU - Baya, B.

AU - Kone, A.

AU - Diabaté, S.

AU - Polis, M. A.

AU - Belson, M.

AU - Dao, S.

AU - Orsega, S.

AU - Achenbach, C. J.

AU - Murphy, R. L.

AU - Diallo, S.

AU - Siddiqui, S.

N1 - Funding Information: The authors would like to acknowledge all SEREFO/ UCRC staff, laboratory and clinical who contributed to patient recruitment, sample processing and data collection. The authors are immensely grateful to the volunteers who participated in the study. This work was supported by the National Institutes of Health (R01AI110386, D43TW010350 and D71 TW010428-01A1). Publisher Copyright: Copyright © 2018 Cambridge University Press.

PY - 2018/2/1

Y1 - 2018/2/1

N2 - The global spread of non-tuberculous mycobacteria (NTM) may be due to HIV/AIDS and other environmental factors. The symptoms of NTM and tuberculosis (TB) disease are indistinguishable, but their treatments are different. Lack of research on the epidemiology of NTM infections has led to underestimation of its prevalence within TB endemic countries. This study was designed to determine the prevalence and clinical characteristics of pulmonary NTM in Bamako. A cross-sectional study which include 439 suspected cases of pulmonary TB. From 2006 to 2013 a total of 332 (76%) were confirmed to have sputum culture positive for mycobacteria. The prevalence of NTM infection was 9.3% of our study population and 12.3% of culture positive patients. The seroprevalence of HIV in NTM group was 17.1%. Patients who weighed <55 kg and had TB symptoms other than cough were also significantly more likely to have disease due to NTM as compared to those with TB disease who were significantly more likely to have cough and weigh more than 55 kg (OR 0.05 (CI 0.02-0.13) and OR 0.32 (CI 0.11-0.93) respectively). NTM disease burden in Bamako was substantial and diagnostic algorithms for pulmonary disease in TB endemic countries should consider the impact of NTM.

AB - The global spread of non-tuberculous mycobacteria (NTM) may be due to HIV/AIDS and other environmental factors. The symptoms of NTM and tuberculosis (TB) disease are indistinguishable, but their treatments are different. Lack of research on the epidemiology of NTM infections has led to underestimation of its prevalence within TB endemic countries. This study was designed to determine the prevalence and clinical characteristics of pulmonary NTM in Bamako. A cross-sectional study which include 439 suspected cases of pulmonary TB. From 2006 to 2013 a total of 332 (76%) were confirmed to have sputum culture positive for mycobacteria. The prevalence of NTM infection was 9.3% of our study population and 12.3% of culture positive patients. The seroprevalence of HIV in NTM group was 17.1%. Patients who weighed <55 kg and had TB symptoms other than cough were also significantly more likely to have disease due to NTM as compared to those with TB disease who were significantly more likely to have cough and weigh more than 55 kg (OR 0.05 (CI 0.02-0.13) and OR 0.32 (CI 0.11-0.93) respectively). NTM disease burden in Bamako was substantial and diagnostic algorithms for pulmonary disease in TB endemic countries should consider the impact of NTM.

KW - Bamako

KW - clinical characteristics

KW - non-tuberculous mycobacteria

KW - tuberculosis

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Clinical characteristics of non-tuberculous mycobacterial pulmonary infections in Bamako, Mali

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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