Clinical evaluation and management of metabolic and morphologic abnormalities associated with human immunodeficiency virus

Christine A. Wanke, J. M. Falutz, Abby Shevitz, J. P. Phair, D. P. Kotler

Research output: Contribution to journalArticlepeer-review

61 Scopus citations

Abstract

In recent years, a spectrum of metabolic and morphologic alterations has emerged among patients infected with human immunodeficiency virus (HIV) receiving antiretroviral treatment. Changes observed include insulin resistance, dyslipidemia, abdominal and dorsocervical fat accumulation, and fat depletion in the extremities and in the face. The health consequences of these changes are not well understood but may include increased risk for diabetes, heart disease, and stroke. Therefore, clinicians that treat patients with HIV need current, practical information on management strategies and interventions for patients with manifestations of HIV-associated lipodystrophy. Literature is reviewed on the health consequences of insulin resistance, dyslipidemia, and alterations in body fat distribution in non-HIV populations to gain perspective on how such abnormalities might affect HIV-infected patients. We also suggest treatments and strategies to manage metabolic and morphologic changes in patients with HIV.

Original languageEnglish (US)
Pages (from-to)248-259
Number of pages12
JournalClinical Infectious Diseases
Volume34
Issue number2
DOIs
StatePublished - Jan 15 2002

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases

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