Clinical Evaluation of the Relative Effectiveness of Multidose Crystalloid and Cold Blood Potassium Cardioplegia in Coronary Artery Bypass Graft Surgery: A Nonrandomized Matched-Pair Analysis

A. J. Roberts, J. M. Moran, J. H. Sanders, S. M. Spies, P. R. Lichtenthal, K. J. Kaplan, L. L. Michaelis

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

Controversy exists concerning the most effective method of myocardial protection during coronary artery bypass graft operations. Accordingly, we performed a matched-pair analysis between 25 patients receiving multidose hypothermic potassium crystalloid cardioplegia and 25 other patients receiving cold blood potassium cardioplegia. Patients were matched on the basis of preoperative ejection fraction (EF) and the number of anatomically similar stenotic coronary arteries. The adequacy of myocardial protection was assessed by serial perioperative determinations of radionuclide ventriculography, hemodynamic measurements, analyses of electrocardiograms, and serum levels of MB-CK. We found that the level of myocardial protection was similar between unstratified groups. However, when subgroups were selected on the basis of prolonged aortic cross-clamp time (> ninety minutes) or impaired preoperative left ventricular function (EF < 40%), there was a suggestion that cold blood cardioplegia may be advantageous.

Original languageEnglish (US)
Pages (from-to)421-433
Number of pages13
JournalAnnals of Thoracic Surgery
Volume33
Issue number5
DOIs
StatePublished - 1982

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Clinical Evaluation of the Relative Effectiveness of Multidose Crystalloid and Cold Blood Potassium Cardioplegia in Coronary Artery Bypass Graft Surgery: A Nonrandomized Matched-Pair Analysis'. Together they form a unique fingerprint.

  • Cite this