Clinical factors associated with worse quality-of-life scores in United States thyroid cancer survivors

Sneha Goswami, Benjamin J. Peipert, Michael N. Mongelli, Sasha K. Kurumety, Irene B. Helenowski, Susan Yount, Cord Sturgeon

Research output: Contribution to journalArticle

Abstract

Introduction: Thyroid cancer survivors are a rapidly growing population in the United States. The factors that drive health-related quality of life (HRQOL) in this population have not been well characterized. We hypothesized that more aggressive treatments and greater treatment-related adverse effects would be associated with worse HRQOL scores in thyroid cancer survivors. Methods: Thyroid cancer survivors (18–89 years of age) completed an online survey regarding their clinical history in addition to the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 instrument. Univariable and multivariable modeling were performed to evaluate factors associated with worse HRQOL scores. We generated β-values and 95% confidence intervals to quantify the effect of each independent variable in the model. Results: Thyroid cancer survivors (n = 1,743) reported a high incidence of complications related to surgery and radioactive iodine ablation. Postoperative dysphonia (ß 1.83–3.07) and dysphagia (ß 2.05–3.65) predicted worse HRQOL scores across multiple PROMIS domains. Younger patient age (age <45 years) and short- or long-term complications of radioactive iodine, including gastrointestinal symptoms (51.9%), appetite changes (71.2%), sialadenitis (58.1%), xerostomia (73.3%), and xerophthalmia (45.1%) were associated with worse HRQOL scores (P < .01). Conclusion: The factors associated with significantly worse HRQOL scores across multiple PROMIS domains for thyroid cancer survivors included patient age <45 years, postoperative hypocalcemia, dysphonia, dysphagia, scar appearance, and complications from radioactive iodine. Methods of evaluation, management, and prevention of these factors might positively impact HRQOL.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalSurgery (United States)
Volume166
Issue number1
DOIs
StatePublished - Jul 1 2019

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Thyroid Neoplasms
Survivors
Quality of Life
Information Systems
Iodine
Dysphonia
Deglutition Disorders
Xerophthalmia
Sialadenitis
Xerostomia
Hypocalcemia
Appetite
Population
Cicatrix
Confidence Intervals
Incidence
Therapeutics
Patient Reported Outcome Measures

ASJC Scopus subject areas

  • Surgery

Cite this

Goswami, Sneha ; Peipert, Benjamin J. ; Mongelli, Michael N. ; Kurumety, Sasha K. ; Helenowski, Irene B. ; Yount, Susan ; Sturgeon, Cord. / Clinical factors associated with worse quality-of-life scores in United States thyroid cancer survivors. In: Surgery (United States). 2019 ; Vol. 166, No. 1. pp. 69-74.
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title = "Clinical factors associated with worse quality-of-life scores in United States thyroid cancer survivors",
abstract = "Introduction: Thyroid cancer survivors are a rapidly growing population in the United States. The factors that drive health-related quality of life (HRQOL) in this population have not been well characterized. We hypothesized that more aggressive treatments and greater treatment-related adverse effects would be associated with worse HRQOL scores in thyroid cancer survivors. Methods: Thyroid cancer survivors (18–89 years of age) completed an online survey regarding their clinical history in addition to the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 instrument. Univariable and multivariable modeling were performed to evaluate factors associated with worse HRQOL scores. We generated β-values and 95{\%} confidence intervals to quantify the effect of each independent variable in the model. Results: Thyroid cancer survivors (n = 1,743) reported a high incidence of complications related to surgery and radioactive iodine ablation. Postoperative dysphonia ({\ss} 1.83–3.07) and dysphagia ({\ss} 2.05–3.65) predicted worse HRQOL scores across multiple PROMIS domains. Younger patient age (age <45 years) and short- or long-term complications of radioactive iodine, including gastrointestinal symptoms (51.9{\%}), appetite changes (71.2{\%}), sialadenitis (58.1{\%}), xerostomia (73.3{\%}), and xerophthalmia (45.1{\%}) were associated with worse HRQOL scores (P < .01). Conclusion: The factors associated with significantly worse HRQOL scores across multiple PROMIS domains for thyroid cancer survivors included patient age <45 years, postoperative hypocalcemia, dysphonia, dysphagia, scar appearance, and complications from radioactive iodine. Methods of evaluation, management, and prevention of these factors might positively impact HRQOL.",
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Clinical factors associated with worse quality-of-life scores in United States thyroid cancer survivors. / Goswami, Sneha; Peipert, Benjamin J.; Mongelli, Michael N.; Kurumety, Sasha K.; Helenowski, Irene B.; Yount, Susan; Sturgeon, Cord.

In: Surgery (United States), Vol. 166, No. 1, 01.07.2019, p. 69-74.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Clinical factors associated with worse quality-of-life scores in United States thyroid cancer survivors

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AU - Peipert, Benjamin J.

AU - Mongelli, Michael N.

AU - Kurumety, Sasha K.

AU - Helenowski, Irene B.

AU - Yount, Susan

AU - Sturgeon, Cord

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N2 - Introduction: Thyroid cancer survivors are a rapidly growing population in the United States. The factors that drive health-related quality of life (HRQOL) in this population have not been well characterized. We hypothesized that more aggressive treatments and greater treatment-related adverse effects would be associated with worse HRQOL scores in thyroid cancer survivors. Methods: Thyroid cancer survivors (18–89 years of age) completed an online survey regarding their clinical history in addition to the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 instrument. Univariable and multivariable modeling were performed to evaluate factors associated with worse HRQOL scores. We generated β-values and 95% confidence intervals to quantify the effect of each independent variable in the model. Results: Thyroid cancer survivors (n = 1,743) reported a high incidence of complications related to surgery and radioactive iodine ablation. Postoperative dysphonia (ß 1.83–3.07) and dysphagia (ß 2.05–3.65) predicted worse HRQOL scores across multiple PROMIS domains. Younger patient age (age <45 years) and short- or long-term complications of radioactive iodine, including gastrointestinal symptoms (51.9%), appetite changes (71.2%), sialadenitis (58.1%), xerostomia (73.3%), and xerophthalmia (45.1%) were associated with worse HRQOL scores (P < .01). Conclusion: The factors associated with significantly worse HRQOL scores across multiple PROMIS domains for thyroid cancer survivors included patient age <45 years, postoperative hypocalcemia, dysphonia, dysphagia, scar appearance, and complications from radioactive iodine. Methods of evaluation, management, and prevention of these factors might positively impact HRQOL.

AB - Introduction: Thyroid cancer survivors are a rapidly growing population in the United States. The factors that drive health-related quality of life (HRQOL) in this population have not been well characterized. We hypothesized that more aggressive treatments and greater treatment-related adverse effects would be associated with worse HRQOL scores in thyroid cancer survivors. Methods: Thyroid cancer survivors (18–89 years of age) completed an online survey regarding their clinical history in addition to the Patient-Reported Outcomes Measurement Information System (PROMIS) 29 instrument. Univariable and multivariable modeling were performed to evaluate factors associated with worse HRQOL scores. We generated β-values and 95% confidence intervals to quantify the effect of each independent variable in the model. Results: Thyroid cancer survivors (n = 1,743) reported a high incidence of complications related to surgery and radioactive iodine ablation. Postoperative dysphonia (ß 1.83–3.07) and dysphagia (ß 2.05–3.65) predicted worse HRQOL scores across multiple PROMIS domains. Younger patient age (age <45 years) and short- or long-term complications of radioactive iodine, including gastrointestinal symptoms (51.9%), appetite changes (71.2%), sialadenitis (58.1%), xerostomia (73.3%), and xerophthalmia (45.1%) were associated with worse HRQOL scores (P < .01). Conclusion: The factors associated with significantly worse HRQOL scores across multiple PROMIS domains for thyroid cancer survivors included patient age <45 years, postoperative hypocalcemia, dysphonia, dysphagia, scar appearance, and complications from radioactive iodine. Methods of evaluation, management, and prevention of these factors might positively impact HRQOL.

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