Clinical features of pheochromocytoma and paraganglioma

Lewis Landsberg*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The clinical features of pheochromocytoma are principally the result of catecholamine release from the tumor. As a consequence alarming, and occasionally spectacular, clinical presentations may occur. Hypertension is the most common manifestation of pheochromocytoma occurring in over 90% of patients. In about 10% the tumor is found during family screening or incidentally noted on imaging for another indication. The typical paroxysm or spell is the most characteristic manifestation, occurring in about 50% of patients. Headache, sweating, and palpitations are the most common symptoms noted during a paroxysm, but chest or abdominal pain is common as well. Although it is not necessary nor desirable to screen all hypertensive patients for pheochromocytoma, certain distinctive features warrant ruling out a chromaffin tumor: “spells,” new carbohydrate intolerance, orthostatic hypotension in the untreated state, malignant hypertension, recent onset hypertension, marked BP lability, Takotsubo cardiomyopathy, adrenal mass on imaging, unanticipated swings in BP in response to drugs or instrumentation, and family history of syndromic pheochromocytoma. The trick is to think of it; once pheochromocytoma is considered, the diagnosis can be readily confirmed or excluded in almost all cases.

Original languageEnglish (US)
Title of host publicationContemporary Endocrinology
PublisherHumana Press Inc
Pages39-61
Number of pages23
DOIs
StatePublished - Jan 1 2018

Publication series

NameContemporary Endocrinology
ISSN (Print)2523-3785
ISSN (Electronic)2523-3793

Keywords

  • Paraganglioma
  • Paroxysms
  • Pheochromocytoma
  • Pressor crises
  • Screening for pheochromocytoma
  • Shock

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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  • Cite this

    Landsberg, L. (2018). Clinical features of pheochromocytoma and paraganglioma. In Contemporary Endocrinology (pp. 39-61). (Contemporary Endocrinology). Humana Press Inc. https://doi.org/10.1007/978-3-319-77048-2_3