Clinical implications and pathogenesis of esophageal remodeling in eosinophilic esophagitis

Ikuo Hirano, Seema S. Aceves*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

75 Scopus citations


In eosinophilic esophagitis (EoE), remodeling changes are manifest histologically in the epithelium and subepithelium where lamina propria fibrosis, expansion of the muscularis propria, and increased vascularity occur. The clinical symptoms and complications of EoE are largely consequences of esophageal remodeling. Available therapies have demonstrated variable ability to reverse existing remodeling changes of the esophagus. Systemic therapies have the potential of addressing subepithelial remodeling. Esophageal dilation remains a useful, adjunctive therapeutic maneuver in symptomatic adults with esophageal stricture. As novel treatments emerge, it is essential that therapeutic end points account for the fundamental contributions of esophageal remodeling to overall disease activity.

Original languageEnglish (US)
Pages (from-to)297-316
Number of pages20
JournalGastroenterology Clinics of North America
Issue number2
StatePublished - Jun 2014


  • Dysphagia
  • Endoscopy
  • Eosinophilic esophagitis
  • Esophagitis
  • Fibrosis
  • Gastroesophageal reflux disease
  • Remodeling

ASJC Scopus subject areas

  • Gastroenterology


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