Clinical implications of molecular neuropathology and biomarkers for malignant glioma

Ghazaleh Tabatabai*, Monika Hegi, Roger Stupp, Michael Weller

*Corresponding author for this work

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

Malignant gliomas are currently diagnosed based on morphological criteria and graded according to theWorld Health Organization classification of primary brain tumors. This algorithm of diagnosis and classification provides clinicians with an estimated prognosis of the natural course of the disease. It does not reflect the expected response to specific treatments beyond surgery (eg, radiotherapy or alkylating chemotherapy). Clinical experience has revealed that gliomas sharing similar histomorphological criteria might indeed have different clinical courses and exhibit highly heterogenous responses to treatments. This was very impressively demonstrated first for oligodendrogliomas. The presence or lack of combined deletions of the chromosomal segments 1p/19q was associated with different benefit from radiotherapy and chemotherapy. We review current molecular markers for malignant gliomas and discuss their current and future impact on clinical neuro-oncology.

Original languageEnglish (US)
Pages (from-to)302-307
Number of pages6
JournalCurrent neurology and neuroscience reports
Volume12
Issue number3
DOIs
Publication statusPublished - Jun 1 2012

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Keywords

  • Biomarker
  • Glioma
  • Molecular diagnostics

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

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