Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: Data from an international inception cohort

Murray B. Urowitz*, D. Gladman, D. Ibañez, P. Fortin, J. Sanchez-Guerrero, S. Bae, A. Clarke, S. Bernatsky, C. Gordon, J. Hanly, D. Wallace, D. Isenberg, E. Ginzler, J. Merrill, G. Alarcon, K. Steinsson, M. Petri, M. A. Dooley, I. Bruce, S. ManziM. Khamashta, R. Ramsey-Goldman, A. Zoma, G. Sturfelt, O. Nived, P. Maddison, J. Font, R. Van Vollenhoven, C. Aranow, K. Kalunian, T. Stoll, J. Buyon

*Corresponding author for this work

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.

Original languageEnglish (US)
Pages (from-to)731-735
Number of pages5
JournalLupus
Volume16
Issue number9
DOIs
StatePublished - Oct 9 2007

Keywords

  • Coronary artery risk factors
  • Inception observation cohort study
  • Lupus

ASJC Scopus subject areas

  • Rheumatology

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    Urowitz, M. B., Gladman, D., Ibañez, D., Fortin, P., Sanchez-Guerrero, J., Bae, S., Clarke, A., Bernatsky, S., Gordon, C., Hanly, J., Wallace, D., Isenberg, D., Ginzler, E., Merrill, J., Alarcon, G., Steinsson, K., Petri, M., Dooley, M. A., Bruce, I., ... Buyon, J. (2007). Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus: Data from an international inception cohort. Lupus, 16(9), 731-735. https://doi.org/10.1177/0961203307081113