TY - JOUR
T1 - Clinical manifestations and coronary artery disease risk factors at diagnosis of systemic lupus erythematosus
T2 - Data from an international inception cohort
AU - Urowitz, Murray B.
AU - Gladman, D.
AU - Ibañez, D.
AU - Fortin, P.
AU - Sanchez-Guerrero, J.
AU - Bae, S.
AU - Clarke, A.
AU - Bernatsky, S.
AU - Gordon, C.
AU - Hanly, J.
AU - Wallace, D.
AU - Isenberg, D.
AU - Ginzler, E.
AU - Merrill, J.
AU - Alarcon, G.
AU - Steinsson, K.
AU - Petri, M.
AU - Dooley, M. A.
AU - Bruce, I.
AU - Manzi, S.
AU - Khamashta, M.
AU - Ramsey-Goldman, R.
AU - Zoma, A.
AU - Sturfelt, G.
AU - Nived, O.
AU - Maddison, P.
AU - Font, J.
AU - Van Vollenhoven, R.
AU - Aranow, C.
AU - Kalunian, K.
AU - Stoll, T.
AU - Buyon, J.
PY - 2007
Y1 - 2007
N2 - Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.
AB - Systemic Lupus International Collaborating Clinics (SLICC) comprises 27 centres from 11 countries. An inception cohort of 918 SLE patients has been assembled according to a standardized protocol between 2000 and 2006. Clinical features, classic coronary artery disease (CAD) risk factors, as well as other potential risk factors were collected. Of the 918 patients 89% were females, and of multi racial origin. Less than half the patients were living in a permanent relationship, 58% had post secondary education and 51% were employed. Eight percent had family history of SLE. At enrolment, with at mean age of diagnosis of 34.5 years, a significant number of patients already had CAD risk factors, such as hypertension (33%) and hypercholesterolemia (36%). Only 15% of the patients were postmenopausal, 16% were current smokers and 3.6% had diabetes at entry to the SLICC-RAS (Registry for Atherosclerosis). A number of patients in this multi-racial, multi-ethnic inception cohort of lupus patients have classic CAD risk factors within a mean of 5.4 months from diagnosis. This cohort will be increased to 1500 patients to be followed yearly for 10 years. This will provide a unique opportunity to evaluate risk factors for accelerated atherosclerosis in SLE.
KW - Coronary artery risk factors
KW - Inception observation cohort study
KW - Lupus
UR - http://www.scopus.com/inward/record.url?scp=34948827357&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34948827357&partnerID=8YFLogxK
U2 - 10.1177/0961203307081113
DO - 10.1177/0961203307081113
M3 - Article
C2 - 17728367
AN - SCOPUS:34948827357
SN - 0961-2033
VL - 16
SP - 731
EP - 735
JO - Lupus
JF - Lupus
IS - 9
ER -
