Clinical manifestations of chronic thiamine deficiency in the rhesus monkey

Marek Marsel Mesulam*, Gary W. Van Hoesen, Nelson Butters

*Corresponding author for this work

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

In the course of multiple episodes of thiamine deficiency in the rhesus monkey, the triad of anorexia, apathy, and hind limb weakness is the earliest clinical manifestation. In later episodes, nystagmus, abducens paresis, midline ataxia, dysmetria, and congestive heart failure are also seen. With the exception of dysmetria, the neurologic signs promptly respond to thiamine administration. Pair-fed controls showed no clinical signs. Neither peripheral neuropathy nor edema was observed. Thiamine deficiency in the experimental animals was confirmed by blood transketolase assays.

Original languageEnglish (US)
Pages (from-to)239-245
Number of pages7
JournalNeurology
Volume27
Issue number3
StatePublished - Jan 1 1977

ASJC Scopus subject areas

  • Clinical Neurology

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