Clinical outcomes for suspicious category in thyroid fine-needle aspiration biopsy patient's sex and nodule size are possible predictors of malignancy

Kirtee Raparia, Soo Kee Min, Dina R. Mody, Rose Anton, Mojgan Amrikachi*

*Corresponding author for this work

Research output: Contribution to journalArticle

59 Scopus citations

Abstract

Context-Fine-needle aspiration (FNA) is recommended as an initial screening tool for the diagnosis of thyroid nodules. Approximately 10% of thyroid FNA diagnoses are ''suspicious for neoplasm,'' warranting surgical resection. Objectives-To examine the role of a patient's age, sex, size of nodule, and morphologic features as possible predictors of malignancy in patients with cytologic diagnosis of ''suspicious for neoplasm.'' Design-Cytopathology slides and reports of 402 consecutive thyroid FNAs from 2000-2005 interpreted as ''suspicious'' were reviewed. Of these, 180 cases that had subsequent surgical resection were selected. Results-Of the 108 cases suspicious for follicular neoplasm on cytologic evaluation, histologic follow-up showed malignancy in 26 (24%). Of the 37 cases suspicious for Hurthle cell neoplasm, 15 (41%) had malignancy. Of the 35 cases suspicious for malignancy, 29 had malignant histologic diagnoses. Among cases with cytologic diagnoses of ''suspicious for follicular or Hurthle cell neoplasm,'' the rate of malignancy in female patients was 22% as compared to 43% in male patients (P =.02). The rate of malignancy in nodules less than 2 cm was 19% compared to 47% in nodules measuring 2 cm or larger (P <.001). These differences were statistically significant. No statistically significant difference was noted between the age of the patient and the rate of benign versus malignant diagnosis. Conclusions-Malignant tumors were more frequent in male patients with a cytologic diagnosis of ''suspicious for follicular or Hurthle cell neoplasm'' than in female patients. Risk of malignancy was higher in nodules measuring 2 cm or larger. Age of the patient was not a predictor of malignancy.

Original languageEnglish (US)
Pages (from-to)787-790
Number of pages4
JournalArchives of Pathology and Laboratory Medicine
Volume133
Issue number5
StatePublished - May 2009

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Medical Laboratory Technology

Fingerprint Dive into the research topics of 'Clinical outcomes for suspicious category in thyroid fine-needle aspiration biopsy patient's sex and nodule size are possible predictors of malignancy'. Together they form a unique fingerprint.

  • Cite this