Clinical pharmacology of linezolid: An oxazolidinone antimicrobial agent

Tina Quanbee Tan; Ram Yogev

doi:10.1586/17512433.1.4.479

Clinical pharmacology of linezolid: An oxazolidinone antimicrobial agent

Tina Quanbee Tan, Ram Yogev^*

^*Corresponding author for this work

Pediatrics

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

The oxazolidinones are a new class of antibiotics whose mechanism of action is the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. Linezolid is the first member of this class of antibiotics to be approved by the US FDA and other regulatory bodies for the treatment of infections caused by antibiotic-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate S. aureus and vancomycin-resistant Enterococcus, in adults and children.

Original language	English (US)
Pages (from-to)	479-489
Number of pages	11
Journal	Expert Review of Clinical Pharmacology
Volume	1
Issue number	4
DOIs	https://doi.org/10.1586/17512433.1.4.479
State	Published - Jul 1 2008

Keywords

Enterococcus
Gram-positive bacteria
Linezolid
Oxazolidinone
Staphydococcus aureus

ASJC Scopus subject areas

Pharmacology, Toxicology and Pharmaceutics(all)
Pharmacology (medical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1586/17512433.1.4.479

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title = "Clinical pharmacology of linezolid: An oxazolidinone antimicrobial agent",

abstract = "The oxazolidinones are a new class of antibiotics whose mechanism of action is the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. Linezolid is the first member of this class of antibiotics to be approved by the US FDA and other regulatory bodies for the treatment of infections caused by antibiotic-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate S. aureus and vancomycin-resistant Enterococcus, in adults and children.",

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author = "Tan, \{Tina Quanbee\} and Ram Yogev",

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AU - Yogev, Ram

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AB - The oxazolidinones are a new class of antibiotics whose mechanism of action is the inhibition of bacterial protein synthesis by binding to the 50S ribosomal subunit. Linezolid is the first member of this class of antibiotics to be approved by the US FDA and other regulatory bodies for the treatment of infections caused by antibiotic-resistant Gram-positive pathogens, such as methicillin-resistant Staphylococcus aureus, glycopeptide-intermediate S. aureus and vancomycin-resistant Enterococcus, in adults and children.

KW - Enterococcus

KW - Gram-positive bacteria

KW - Linezolid

KW - Oxazolidinone

KW - Staphydococcus aureus

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Clinical pharmacology of linezolid: An oxazolidinone antimicrobial agent

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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