TY - JOUR
T1 - Clinical problem-solving
T2 - Decision making by Analogy
AU - Meyer, Catherine
AU - Berczeller, Peter H.
AU - Needles, Carl F.
AU - Green, David
AU - Parise, Pasquale
AU - Berrettini, Mauro
AU - Kettler, Robert E.
AU - Greenberg, Deborah L.
AU - Root, Richard K.
PY - 1995/7/13
Y1 - 1995/7/13
N2 - To the Editor: The patient with possible systemic lupus erythematosus described in the March 2 Clinical Problem-Solving article1 most likely had primary or secondary antiphospholipid-antibody syndrome.2,3 She had documented thrombi in both legs, along with an unexplained elevation in partial-thromboplastin time and a positive test for lupus anticoagulant. These serologic abnormalities, and occasionally a decrease in platelet count, are characteristic of antiphospholipid-antibody syndrome. A test for anticardiolipin antibodies was apparently not done. The antiphospholipid-antibody syndrome occurs in up to one third of patients with systemic lupus.3 The presence of anticardiolipin antibodies would be consistent with this patient's clinical picture. . .
AB - To the Editor: The patient with possible systemic lupus erythematosus described in the March 2 Clinical Problem-Solving article1 most likely had primary or secondary antiphospholipid-antibody syndrome.2,3 She had documented thrombi in both legs, along with an unexplained elevation in partial-thromboplastin time and a positive test for lupus anticoagulant. These serologic abnormalities, and occasionally a decrease in platelet count, are characteristic of antiphospholipid-antibody syndrome. A test for anticardiolipin antibodies was apparently not done. The antiphospholipid-antibody syndrome occurs in up to one third of patients with systemic lupus.3 The presence of anticardiolipin antibodies would be consistent with this patient's clinical picture. . .
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U2 - 10.1056/NEJM199507133330213
DO - 10.1056/NEJM199507133330213
M3 - Letter
C2 - 7777022
SN - 0028-4793
VL - 333
SP - 127
EP - 129
JO - New England Journal of Medicine
JF - New England Journal of Medicine
IS - 2
ER -