Clinical problem-solving: Decision making by Analogy

Catherine Meyer, Peter H. Berczeller, Carl F. Needles, David Green, Pasquale Parise, Mauro Berrettini, Robert E. Kettler, Deborah L. Greenberg, Richard K. Root

Research output: Contribution to journalLetterpeer-review


To the Editor: The patient with possible systemic lupus erythematosus described in the March 2 Clinical Problem-Solving article1 most likely had primary or secondary antiphospholipid-antibody syndrome.2,3 She had documented thrombi in both legs, along with an unexplained elevation in partial-thromboplastin time and a positive test for lupus anticoagulant. These serologic abnormalities, and occasionally a decrease in platelet count, are characteristic of antiphospholipid-antibody syndrome. A test for anticardiolipin antibodies was apparently not done. The antiphospholipid-antibody syndrome occurs in up to one third of patients with systemic lupus.3 The presence of anticardiolipin antibodies would be consistent with this patient's clinical picture. . .

Original languageEnglish (US)
Pages (from-to)127-129
Number of pages3
JournalNew England Journal of Medicine
Issue number2
StatePublished - Jul 13 1995

ASJC Scopus subject areas

  • General Medicine


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