Clinical processes and central dopaminergic activity in psychotic disorders

M. B. Bowers*, G. R. Heninger, D. Sternberg, H. Y. Meltzer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

This study examined the relationship between clinical processes in psychosis and indices of central dopaminergic activity. CSF HVA or GABA, plasma HVA, or serum prolactin did not correlate significantly with the amount of neuroleptic discontinued or the discontinuation interval in a group of psychotic patients approximately three weeks after neuroleptic discontinuation. In this group plus five other patients not recently treated with neuroleptics, the primary pattern of significant correlations was between symptoms of increased arousal and agitation and one or more HVA measure (positive) and CSF GABA (negative). Duration of illness (or drug treatment) was significantly negatively correlated with AM serum prolactin.

Original languageEnglish (US)
Pages (from-to)177-183
Number of pages7
JournalCommunications In Psychopharmacology
Volume4
Issue number3
StatePublished - 1980

ASJC Scopus subject areas

  • Medicine(all)

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