Clinical Risk Factors Associated With Urethral Atrophy

Boyd R. Viers, Shawn Mathur, Matthias D. Hofer, Daniel D. Dugi, Travis J. Pagliara, Nirmish Singla, Jordon Walker, Jeremy M. Scott, Allen F. Morey*

*Corresponding author for this work

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Objective To analyze a series of clinical risk factors associated with pretreatment urethral atrophy. Methods We retrospectively reviewed 301 patients who underwent artificial urinary sphincter (AUS) placement between September 2009 and November 2015; of these, 60 (19.9%) transcorporal cuff patients were excluded. Patients were stratified into 2 groups based on intraoperative spongiosal circumference measurements. Men with urethral atrophy (3.5 cm cuff size) were compared to controls (≥4 cm cuff size). Chi-square test, Mann-Whitney U test, and logistic regression analyses were performed to determine risk factors for urethral atrophy. Results Among 241 AUS patients analyzed, urethral atrophy was present in 151 patients (62.7%) compared to 90 patients (37.3%) who received larger cuffs (range 4-5.5 cm). Patients with urethral atrophy were older (71.1years vs 68.3 years; P < .02), more likely to have received radiation (52.9% vs. 33.3%; P < .007), and had a longer time interval between prostate cancer treatment and AUS surgery (8.9 years vs. 6.6 years; P < .033). On multivariable analysis, radiation therapy was independently associated with risk of urethral atrophy (odds ratio 1.77, 95% confidence interval: 1.01-3.13; P = .046), whereas greater time between cancer therapy and incontinence surgery approached clinical significance (odds ratio 1.05, 95% confidence interval 1.00-1.09; P = .05). Conclusion History of radiation therapy and increasing length of time from prostate cancer treatment are associated with urethral atrophy before AUS placement.

Original languageEnglish (US)
Pages (from-to)230-233
Number of pages4
JournalUrology
Volume103
DOIs
StatePublished - May 2017

ASJC Scopus subject areas

  • Urology

Fingerprint Dive into the research topics of 'Clinical Risk Factors Associated With Urethral Atrophy'. Together they form a unique fingerprint.

  • Cite this

    Viers, B. R., Mathur, S., Hofer, M. D., Dugi, D. D., Pagliara, T. J., Singla, N., Walker, J., Scott, J. M., & Morey, A. F. (2017). Clinical Risk Factors Associated With Urethral Atrophy. Urology, 103, 230-233. https://doi.org/10.1016/j.urology.2016.12.012