Clinical significance of the presence of cryoglobulins in patients with glomerulopathies not associated with systemic disease

E. H. Garin, R. S. Fennell, S. T. Shulman, A. Iravani, G. A. Richard

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

Serial serum samples from 102 children with glomerulopathies not associated with systemic diseases and from 23 normal controls were examined for the presence of cryoglobulins. Sera from controls, from patients with glomerulopathies thought to be mediated by immune complexes, and from those with non-immunologically mediated glomerulopathies demonstrated similar incidence of cryoglobulins. There was no correlation between cryoglobulin concentration or composition and the glomerular immunohistologic findings. Furthermore, persistence of cryoglobulinemia could not be correlated with progression of renal disease. Although cryoglobulins may contain immune complexes, determination of serum cryoglobulin concentration appears to be of little value in the diagnosis of immune complex mediated renal disease, nor in the assessment of disease activity or monitoring therapy in patients with glomerulopathies unassociated with systemic disease.

Original languageEnglish (US)
Pages (from-to)5-11
Number of pages7
JournalClinical Nephrology
Volume13
Issue number1
StatePublished - May 2 1980

ASJC Scopus subject areas

  • Nephrology

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