Clinical trajectories and biological features of Primary Progressive Aphasia (PPA)

E. J. Rogalski, M. M. Mesulam

Research output: Contribution to journalArticlepeer-review

45 Scopus citations


Primary Progressive Aphasia (PPA) is a neurodegenerative syndrome characterized by a gradual dissolution of language, but relative sparing of other cognitive domains during the initial stages of the disease. Research has led to substantial progress in understanding the clinical characteristics, genetics, and neuropathology of this syndrome. This article reviews the clinical criteria for diagnosing PPA, discusses the utility of defining the mild cognitive impairment (MCI) stage of PPA, and highlights some of the more recent research advances particularly in the area of pathology and genetics.

Original languageEnglish (US)
Pages (from-to)331-336
Number of pages6
JournalCurrent Alzheimer Research
Issue number4
StatePublished - Aug 2009


  • Anomia
  • Dementia
  • Frontotemporal dementia
  • Frontotemporal lobar degeneration
  • Primary progressive aphasia
  • Progressive nonfluent aphasia
  • Semantic dementia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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