TY - JOUR
T1 - Clinical utility of laboratory detection of clostridium difficile strain BI/NAP1/027
AU - Kociolek, Larry K.
AU - Gerding, Dale N.
N1 - Publisher Copyright:
© 2015, American Society for Microbiology. All Rights Reserved.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2016/1
Y1 - 2016/1
N2 - Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited.
AB - Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited.
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U2 - 10.1128/JCM.02340-15
DO - 10.1128/JCM.02340-15
M3 - Review article
C2 - 26511742
AN - SCOPUS:84954357970
VL - 54
SP - 19
EP - 24
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 1
ER -