Clinical utility of laboratory detection of clostridium difficile strain BI/NAP1/027

Larry K. Kociolek*, Dale N. Gerding

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

12 Scopus citations


Clostridium difficile strain BI/NAP1/027 is associated with increased C. difficile infection (CDI) rates and severity, and the efficacy of some CDI therapies may be strain dependent. Although cultured C. difficile isolates can be reliably subtyped by various methods, the long turnaround times, high cost, and limited availability of strain typing preclude their routine use. Nucleic acid amplification tests identify BI/NAP1/027 rapidly from stool, but the emergence of closely related strains compromises test specificity. Although detection of epidemiologically significant pathogens is generally useful for infection control programs, specific data supporting use of rapid detection of BI/NAP1/027 as an infection control tool are still awaited.

Original languageEnglish (US)
Pages (from-to)19-24
Number of pages6
JournalJournal of clinical microbiology
Issue number1
StatePublished - Jan 2016

ASJC Scopus subject areas

  • Microbiology (medical)


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