Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: Preclinical validation for clinical translation

Kangan Li, Andrew C. Gordon, Linfeng Zheng, Weiguo Li, Yang Guo, Jing Sun, Guixiang Zhang, Guohong Han, Andrew C. Larson, Zhuoli Zhang*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Aim: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. Materials & methods: Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. Results: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. Conclusion: IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.

Original languageEnglish (US)
Pages (from-to)1761-1774
Number of pages14
JournalNanomedicine
Volume10
Issue number11
DOIs
StatePublished - Jun 1 2015

Keywords

  • MRI
  • liver tumor
  • natural killer cell
  • portal vein
  • rat
  • transcatheter delivery

ASJC Scopus subject areas

  • Bioengineering
  • Medicine (miscellaneous)
  • Biomedical Engineering
  • Materials Science(all)

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