Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: Preclinical validation for clinical translation

Kangan Li; Andrew C. Gordon; Linfeng Zheng; Weiguo Li; Yang Guo; Jing Sun; Guixiang Zhang; Guohong Han; Andrew C. Larson; Zhuoli Zhang

doi:10.2217/nnm.15.24

Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors: Preclinical validation for clinical translation

Kangan Li, Andrew C. Gordon, Linfeng Zheng, Weiguo Li, Yang Guo, Jing Sun, Guixiang Zhang, Guohong Han, Andrew C. Larson, Zhuoli Zhang^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Aim: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. Materials & methods: Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. Results: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. Conclusion: IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.

Original language	English (US)
Pages (from-to)	1761-1774
Number of pages	14
Journal	Nanomedicine
Volume	10
Issue number	11
DOIs	https://doi.org/10.2217/nnm.15.24
State	Published - Jun 1 2015

Keywords

MRI
liver tumor
natural killer cell
portal vein
rat
transcatheter delivery

ASJC Scopus subject areas

Bioengineering
Medicine (miscellaneous)
Biomedical Engineering
Materials Science(all)

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Li, Kangan ; Gordon, Andrew C. ; Zheng, Linfeng ; Li, Weiguo ; Guo, Yang ; Sun, Jing ; Zhang, Guixiang ; Han, Guohong ; Larson, Andrew C. ; Zhang, Zhuoli. / Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors : Preclinical validation for clinical translation. In: Nanomedicine. 2015 ; Vol. 10, No. 11. pp. 1761-1774.

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abstract = "Aim: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. Materials & methods: Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. Results: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. Conclusion: IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.",

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Clinically applicable magnetic-labeling of natural killer cells for MRI of transcatheter delivery to liver tumors : Preclinical validation for clinical translation. / Li, Kangan; Gordon, Andrew C.; Zheng, Linfeng; Li, Weiguo; Guo, Yang; Sun, Jing; Zhang, Guixiang; Han, Guohong; Larson, Andrew C.; Zhang, Zhuoli.

In: Nanomedicine, Vol. 10, No. 11, 01.06.2015, p. 1761-1774.

Research output: Contribution to journal › Article › peer-review

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T2 - Preclinical validation for clinical translation

AU - Li, Kangan

AU - Gordon, Andrew C.

AU - Zheng, Linfeng

AU - Li, Weiguo

AU - Guo, Yang

AU - Sun, Jing

AU - Zhang, Guixiang

AU - Han, Guohong

AU - Larson, Andrew C.

AU - Zhang, Zhuoli

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N2 - Aim: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. Materials & methods: Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. Results: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. Conclusion: IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.

AB - Aim: To test the hypothesis that MRI can monitor intraportal vein (IPV) transcatheter delivery of clinically applicable heparin-protamine-ferumoxytol (HPF) nanocomplex-labeled natural killer (NK) cells to liver tumor. Materials & methods: Liver tumor rat models underwent catheterization for IPV infusion of HPF-labeled NK cells (NK-92MI cell line). MRI measurements within tumor and adjacent liver tissues were compared pre- and post-NK cell infusion. Histology studies were used to identify NK cells in the target tumors. Results: For first time, we demonstrated that MRI tracks HPF-labeled NK cells migration within liver following IPV delivery. Conclusion: IPV transcatheter infusion permitted selective delivery of NK cells to liver tissues and MRI allowed tracking NK cell biodistributions within the tumors.

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