Clinicopathologic features and treatment trends of pancreatic neuroendocrine tumors: Analysis of 9,821 patients

Karl Y. Bilimoria; James S. Tomlinson; Ryan P. Merkow; Andrew K. Stewart; Clifford Y. Ko; Mark S. Talamonti; David J. Bentrem

doi:10.1007/s11605-007-0263-3

Clinicopathologic features and treatment trends of pancreatic neuroendocrine tumors: Analysis of 9,821 patients

Karl Y. Bilimoria, James S. Tomlinson, Ryan P. Merkow, Andrew K. Stewart, Clifford Y. Ko, Mark S. Talamonti, David J. Bentrem^*

^*Corresponding author for this work

Surgery, Surgical Oncology Division

Research output: Contribution to journal › Article › peer-review

131 Scopus citations

Abstract

The natural history of pancreatic neuroendocrine tumors (PNET) remains poorly defined. Our objectives were to examine the clinicopathologic features of PNETs, to assess treatment trends over time, and to identify factors associated with undergoing resection. From the National Cancer Data Base (1985-2004), 9,821 patients were identified with PNETs. Clinicopathologic features and treatment trends were examined. Multivariable logistic regression was used to assess factors associated with undergoing resection. Of 9,821 patients with PNETs, 85% were nonfunctional, 7.1% were functional, and 7.9% were carcinoid tumors. Of the 3,851 (39.0%) patients who underwent pancreatectomy, 449 (11.7%) received adjuvant chemotherapy, and 254 (6.6%) received adjuvant radiation. From 1985 to 2004, utilization of pancreatectomy increased from 39.4 to 44.3% (P∈<∈0.0001). Patients were less likely to undergo resection if they were >55 years old, had tumors in the head of the pancreas, tumors ≥4 cm, or had distant metastases (P∈<∈0.0001). Patients treated at NCCN/NCI, academic, or high-volume hospitals were more likely to undergo resection. There are disparities in the utilization of pancreatectomy for PNETs. As PNETs have a better prognosis than adenocarcinoma, concerns regarding the morbidity and mortality of pancreatic surgery and neoplasms should not preclude resection.

Original language	English (US)
Pages (from-to)	1460-1469
Number of pages	10
Journal	Journal of Gastrointestinal Surgery
Volume	11
Issue number	11
DOIs	https://doi.org/10.1007/s11605-007-0263-3
State	Published - Nov 2007

Funding

Acknowledgements KYB is supported by the American College of Surgeons, Clinical Scholars in Residence program and a research grant from the Department of Surgery, Feinberg School of Medicine, Northwestern University. This study was presented in part at the 48th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) meeting at Digestive Disease Week 2007 in Washington, DC on May 23, 2007.

Keywords

National Cancer Data Base
Pancreatectomy
Pancreatic neuroendocrine tumors
Surgery

ASJC Scopus subject areas

Surgery
Gastroenterology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1007/s11605-007-0263-3

Cite this

@article{89f7c976acb146f28215aeef4da3f10a,

title = "Clinicopathologic features and treatment trends of pancreatic neuroendocrine tumors: Analysis of 9,821 patients",

abstract = "The natural history of pancreatic neuroendocrine tumors (PNET) remains poorly defined. Our objectives were to examine the clinicopathologic features of PNETs, to assess treatment trends over time, and to identify factors associated with undergoing resection. From the National Cancer Data Base (1985-2004), 9,821 patients were identified with PNETs. Clinicopathologic features and treatment trends were examined. Multivariable logistic regression was used to assess factors associated with undergoing resection. Of 9,821 patients with PNETs, 85% were nonfunctional, 7.1% were functional, and 7.9% were carcinoid tumors. Of the 3,851 (39.0%) patients who underwent pancreatectomy, 449 (11.7%) received adjuvant chemotherapy, and 254 (6.6%) received adjuvant radiation. From 1985 to 2004, utilization of pancreatectomy increased from 39.4 to 44.3% (P∈<∈0.0001). Patients were less likely to undergo resection if they were >55 years old, had tumors in the head of the pancreas, tumors ≥4 cm, or had distant metastases (P∈<∈0.0001). Patients treated at NCCN/NCI, academic, or high-volume hospitals were more likely to undergo resection. There are disparities in the utilization of pancreatectomy for PNETs. As PNETs have a better prognosis than adenocarcinoma, concerns regarding the morbidity and mortality of pancreatic surgery and neoplasms should not preclude resection.",

keywords = "National Cancer Data Base, Pancreatectomy, Pancreatic neuroendocrine tumors, Surgery",

author = "Bilimoria, {Karl Y.} and Tomlinson, {James S.} and Merkow, {Ryan P.} and Stewart, {Andrew K.} and Ko, {Clifford Y.} and Talamonti, {Mark S.} and Bentrem, {David J.}",

note = "Funding Information: Acknowledgements KYB is supported by the American College of Surgeons, Clinical Scholars in Residence program and a research grant from the Department of Surgery, Feinberg School of Medicine, Northwestern University. This study was presented in part at the 48th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) meeting at Digestive Disease Week 2007 in Washington, DC on May 23, 2007.",

year = "2007",

month = nov,

doi = "10.1007/s11605-007-0263-3",

language = "English (US)",

volume = "11",

pages = "1460--1469",

journal = "Journal of Gastrointestinal Surgery",

issn = "1091-255X",

publisher = "Springer New York",

number = "11",

}

TY - JOUR

T1 - Clinicopathologic features and treatment trends of pancreatic neuroendocrine tumors

T2 - Analysis of 9,821 patients

AU - Bilimoria, Karl Y.

AU - Tomlinson, James S.

AU - Merkow, Ryan P.

AU - Stewart, Andrew K.

AU - Ko, Clifford Y.

AU - Talamonti, Mark S.

AU - Bentrem, David J.

N1 - Funding Information: Acknowledgements KYB is supported by the American College of Surgeons, Clinical Scholars in Residence program and a research grant from the Department of Surgery, Feinberg School of Medicine, Northwestern University. This study was presented in part at the 48th Annual Meeting of the Society for Surgery of the Alimentary Tract (SSAT) meeting at Digestive Disease Week 2007 in Washington, DC on May 23, 2007.

PY - 2007/11

Y1 - 2007/11

N2 - The natural history of pancreatic neuroendocrine tumors (PNET) remains poorly defined. Our objectives were to examine the clinicopathologic features of PNETs, to assess treatment trends over time, and to identify factors associated with undergoing resection. From the National Cancer Data Base (1985-2004), 9,821 patients were identified with PNETs. Clinicopathologic features and treatment trends were examined. Multivariable logistic regression was used to assess factors associated with undergoing resection. Of 9,821 patients with PNETs, 85% were nonfunctional, 7.1% were functional, and 7.9% were carcinoid tumors. Of the 3,851 (39.0%) patients who underwent pancreatectomy, 449 (11.7%) received adjuvant chemotherapy, and 254 (6.6%) received adjuvant radiation. From 1985 to 2004, utilization of pancreatectomy increased from 39.4 to 44.3% (P∈<∈0.0001). Patients were less likely to undergo resection if they were >55 years old, had tumors in the head of the pancreas, tumors ≥4 cm, or had distant metastases (P∈<∈0.0001). Patients treated at NCCN/NCI, academic, or high-volume hospitals were more likely to undergo resection. There are disparities in the utilization of pancreatectomy for PNETs. As PNETs have a better prognosis than adenocarcinoma, concerns regarding the morbidity and mortality of pancreatic surgery and neoplasms should not preclude resection.

AB - The natural history of pancreatic neuroendocrine tumors (PNET) remains poorly defined. Our objectives were to examine the clinicopathologic features of PNETs, to assess treatment trends over time, and to identify factors associated with undergoing resection. From the National Cancer Data Base (1985-2004), 9,821 patients were identified with PNETs. Clinicopathologic features and treatment trends were examined. Multivariable logistic regression was used to assess factors associated with undergoing resection. Of 9,821 patients with PNETs, 85% were nonfunctional, 7.1% were functional, and 7.9% were carcinoid tumors. Of the 3,851 (39.0%) patients who underwent pancreatectomy, 449 (11.7%) received adjuvant chemotherapy, and 254 (6.6%) received adjuvant radiation. From 1985 to 2004, utilization of pancreatectomy increased from 39.4 to 44.3% (P∈<∈0.0001). Patients were less likely to undergo resection if they were >55 years old, had tumors in the head of the pancreas, tumors ≥4 cm, or had distant metastases (P∈<∈0.0001). Patients treated at NCCN/NCI, academic, or high-volume hospitals were more likely to undergo resection. There are disparities in the utilization of pancreatectomy for PNETs. As PNETs have a better prognosis than adenocarcinoma, concerns regarding the morbidity and mortality of pancreatic surgery and neoplasms should not preclude resection.

KW - National Cancer Data Base

KW - Pancreatectomy

KW - Pancreatic neuroendocrine tumors

KW - Surgery

UR - http://www.scopus.com/inward/record.url?scp=35148863221&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=35148863221&partnerID=8YFLogxK

U2 - 10.1007/s11605-007-0263-3

DO - 10.1007/s11605-007-0263-3

M3 - Article

C2 - 17846854

AN - SCOPUS:35148863221

SN - 1091-255X

VL - 11

SP - 1460

EP - 1469

JO - Journal of Gastrointestinal Surgery

JF - Journal of Gastrointestinal Surgery

IS - 11

ER -

Clinicopathologic features and treatment trends of pancreatic neuroendocrine tumors: Analysis of 9,821 patients

Abstract

Funding

Keywords

ASJC Scopus subject areas

UN SDGs

Access to Document

Other files and links

Fingerprint

Cite this