Clinicopathologic features and treatment trends of pancreatic neuroendocrine tumors: Analysis of 9,821 patients

Karl Y. Bilimoria, James S. Tomlinson, Ryan P. Merkow, Andrew K. Stewart, Clifford Y. Ko, Mark S. Talamonti, David J. Bentrem*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

104 Scopus citations

Abstract

The natural history of pancreatic neuroendocrine tumors (PNET) remains poorly defined. Our objectives were to examine the clinicopathologic features of PNETs, to assess treatment trends over time, and to identify factors associated with undergoing resection. From the National Cancer Data Base (1985-2004), 9,821 patients were identified with PNETs. Clinicopathologic features and treatment trends were examined. Multivariable logistic regression was used to assess factors associated with undergoing resection. Of 9,821 patients with PNETs, 85% were nonfunctional, 7.1% were functional, and 7.9% were carcinoid tumors. Of the 3,851 (39.0%) patients who underwent pancreatectomy, 449 (11.7%) received adjuvant chemotherapy, and 254 (6.6%) received adjuvant radiation. From 1985 to 2004, utilization of pancreatectomy increased from 39.4 to 44.3% (P∈<∈0.0001). Patients were less likely to undergo resection if they were >55 years old, had tumors in the head of the pancreas, tumors ≥4 cm, or had distant metastases (P∈<∈0.0001). Patients treated at NCCN/NCI, academic, or high-volume hospitals were more likely to undergo resection. There are disparities in the utilization of pancreatectomy for PNETs. As PNETs have a better prognosis than adenocarcinoma, concerns regarding the morbidity and mortality of pancreatic surgery and neoplasms should not preclude resection.

Original languageEnglish (US)
Pages (from-to)1460-1469
Number of pages10
JournalJournal of Gastrointestinal Surgery
Volume11
Issue number11
DOIs
StatePublished - Nov 2007

Keywords

  • National Cancer Data Base
  • Pancreatectomy
  • Pancreatic neuroendocrine tumors
  • Surgery

ASJC Scopus subject areas

  • Surgery
  • Gastroenterology

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