Clinicopathological study in progressive supranuclear palsy with pedunculopontine stimulation

Lili Naz Hazrati*, Janice C. Wong, Clement Hamani, Andres M. Lozano, Yu Yan Poon, Jonathan O. Dostrovsky, William D. Hutchison, Cindy Zadikoff, Elena Moro

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

25 Scopus citations

Abstract

Background: Pedunculopontine nucleus (PPN) DBS has emerged as a potential intervention for patients with gait and balance disorders. However, targeting this nucleus can be challenging. We report on the first neuropathological analyses after PPN-DBS surgery in advanced progressive supranuclear palsy (PSP). Methods: Two patients with PSP underwent unilateral PPN-DBS surgery and were clinically followed to autopsy. Both patients underwent postmortem neuropathological analysis, including choline acetyltransferase immunohistochemistry, to ascertain PPN boundaries and electrode location. Results: Both patients experienced partial improvement in some motor and nonmotor domains postintervention, but died shortly of other complications. Postmortem neuropathological analysis of each patient confirmed the electrode in a region of cholinergic neuronal loss corresponding to the PPN. Conclusions: We provide histopathological evidence for the validity of our stereotactic approach to target the PPN and correlate electrode location with clinical outcomes.

Original languageEnglish (US)
Pages (from-to)1304-1307
Number of pages4
JournalMovement Disorders
Volume27
Issue number10
DOIs
StatePublished - Sep 1 2012

Keywords

  • Deep brain stimulation
  • Neuropathology
  • Pedunculopontine nucleus
  • Progressive supranuclear palsy

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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