Clock Gene Regulation of Endocrine Function

F. W. Turek*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Hormones of diverse endocrine systems fluctuate in a regular fashion throughout the 24 h day, providing a high degree of temporal organization within the endocrine milieu of the organism. While it has been known that these diurnal fluctuations are under the control of a central circadian clock located in the master neuroendocrine regulator of the brain, the hypothalamus, only recently has the molecular transcriptional-translational feedback loop that gives rise to the generation of 24 h signals at the cellular level been uncovered. Our understanding of how alterations in circadian clock gene function can lead to changes in 24 h hormonal patterns is at only an early stage, but these early studies indicate that such alterations could underlie diverse endocrine pathophysiologies.

Original languageEnglish (US)
Title of host publicationEncyclopedia of Neuroscience
PublisherElsevier Ltd
Pages1019-1021
Number of pages3
ISBN (Print)9780080450469
DOIs
StatePublished - Jan 1 2009

Keywords

  • Circadian
  • Diabetes
  • Genetics
  • Growth hormone
  • Hormones
  • Hypothalamus
  • Metabolism
  • Night eating disorders
  • Obesity
  • Pineal gland
  • Pituitary gland
  • Reproduction
  • Sleep
  • Suprachiasmatic nucleus

ASJC Scopus subject areas

  • Neuroscience(all)

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